Document Detail

Zinc status and growth of children undergoing treatment for phenylketonuria.
MedLine Citation:
PMID:  6820419     Owner:  NLM     Status:  MEDLINE    
Children with phenylketonuria (PKU) are treated with semi-synthetic diets restricted in phenylalanine. Low-phenylalanine or phenylalanine-free formulae provide the majority of protein and energy in the diet while phenylalanine requirements are met by low-protein natural foods. Because of the restriction of natural protein sources in this diet, the study assessed the zinc nutrition of 22 treated children with PKU (aged from 1 month to 8 1/2 years) and correlated linear growth with zinc status. The mean (+/- SE) plasma zinc concentration of the PKU population was 66.6 +/- 3.3 micrograms/dl. The mean (+/- SE) hair zinc concentration was 70.2 +/- 11.5 micrograms/g. The mean plasma and hair zinc concentrations of the PKU population were significantly different (p less than 0.05) when compared with mean (+/- SE) normal values of 84.2 +/- 2.9 micrograms/dl and 130.7 +/- 8.3 micrograms/g, respectively. The mean (+/- SD) dietary zinc intake of 10 PKU patients was 8.56 +/- 2.68 mg/day. No significant differences (p less than 0.123) were found when the mean zinc intake was compared with National Academy of Sciences Recommended Dietary Allowance for age of 10 mg/day. No significant correlations were found when plasma and hair zinc concentrations were plotted with height percentiles. Further studies are required to assess the effects of zinc supplementation and the bioavailability of zinc from low-phenylalanine diets.
P B Acosta; P M Fernhoff; H S Warshaw; L J Elsas; K M Hambidge; A Ernest; E R McCabe
Related Documents :
1473789 - Chronic oral toxicity and carcinogenicity study of stevioside in rats.
21209019 - Leptin-independent programming of adult body weight and adiposity in mice.
3339479 - Metallothionein gene expression in rats: tissue-specific regulation by dietary copper a...
9771929 - Zinc replenishment reduces esophageal cell proliferation and n-nitrosomethylbenzylamine...
7233449 - The influence of high dietary zinc on tissue disposition and urinary excretion of cadmi...
3584729 - Effect of zinc supplements on the intestinal absorption of calcium.
3618769 - Brown adipose tissue metabolism in ob/ob mice: effects of a high-fat diet and adrenalec...
9252929 - Estrogen-androgen for hormone replacement. a review.
21491249 - Effect of three mycotoxin adsorbents on growth performance, nutrient retention and meat...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  5     ISSN:  0141-8955     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  1982  
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-10     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Food, Formulated*
Hair / analysis
Phenylketonurias / diet therapy*,  physiopathology
Zinc / blood,  metabolism*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intermittent hypermethioninaemia associated with normal hepatic methionine adenosyltransferase activ...
Next Document:  Normal hydroxylation of proline in collagen synthesized by skin fibroblasts from a patient with prol...