Document Detail

Zinc regulation of food intake: new insights on the role of neuropeptide Y.
MedLine Citation:
PMID:  12918877     Owner:  NLM     Status:  MEDLINE    
The role of neuropeptide Y (NPY) in feeding behavior and zinc deficiency-induced anorexia has been controversial because hypothalamic NPY levels are elevated in both zinc deficiency and food restriction. A recent report shows that while NPY is released from terminals in the paraventricular nucleus of the hypothalamus of food-restricted animals, this release is significantly impaired in zinc-deficient animals. Zinc deficiency may therefore cause anorexia by inhibiting the release of NPY that is required for receptor activation.
Cathy W Levenson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  61     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-15     Completed Date:  2003-08-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-9     Citation Subset:  IM    
Florida State University, Program in Neuroscience, Department of Nutrition, Food & Exercise Sciences, 237 Biomedical Research Facility, Tallahassee, FL 32306-4340, USA.
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MeSH Terms
Anorexia Nervosa / drug therapy,  metabolism*
Eating / drug effects*
Neuropeptide Y / metabolism,  physiology*
Zinc / deficiency*,  metabolism,  pharmacology
Reg. No./Substance:
0/Neuropeptide Y; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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