Document Detail

Zinc-regulated biosynthesis of immunodominant antigens from Aspergillus spp.
MedLine Citation:
PMID:  10225898     Owner:  NLM     Status:  MEDLINE    
ASPND1 and ASPF2 are immunodominant antigens from Aspergillus nidulans and A. fumigatus, respectively, that are readily synthesized in infections in the human host, as demonstrated by their reactivity with more than 80% of sera from patients with aspergilloma or allergic bronchopulmonary aspergillosis. We demonstrate here that both antigens are exclusively produced under situations of low bioavailability of free Zn2+. Addition of micromolar concentrations of Zn2+ to the culture medium strongly stimulated Aspergillus growth but totally inhibited ASPND1 or ASPF2 production. This effect was specific, since other divalent metals had no effect. Removal of endogenous Zn2+ by a chelator also stimulated ASPND1 production, and the effect was specifically reversed by Zn2+. These results suggest a possible role of these antigens in the survival of the fungus in the lungs.
M Segurado; R López-Aragón; J A Calera; J M Fernández-Abalos; F Leal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  67     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-05-18     Completed Date:  1999-05-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2377-82     Citation Subset:  IM    
Departamento de Microbiología y Genética, Universidad de Salamanca, 37007 Salamanca, Spain.
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MeSH Terms
Antigens, Fungal / biosynthesis*
Aspergillosis, Allergic Bronchopulmonary / microbiology
Aspergillus / drug effects*,  immunology*,  pathogenicity
Aspergillus fumigatus / drug effects,  immunology,  pathogenicity
Aspergillus nidulans / drug effects,  immunology,  pathogenicity
Culture Media
Fungal Proteins / biosynthesis
Glycoproteins / biosynthesis
Immunodominant Epitopes / biosynthesis
Opportunistic Infections / microbiology
Virulence / drug effects,  immunology
Zinc / pharmacology*
Reg. No./Substance:
0/ASPND1 protein, Aspergillus nidulans; 0/Antigens, Fungal; 0/Culture Media; 0/Fungal Proteins; 0/Glycoproteins; 0/Immunodominant Epitopes; 0/allergen Asp f 2, Aspergillus fumigatus; 7440-66-6/Zinc

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