Document Detail


Zinc protoporphyrin, a useful parameter to address hyperferritinemia.
MedLine Citation:
PMID:  17333188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zinc protoporphyrin (ZPP) is produced instead of heme as soon as iron support to erythropoiesis becomes insufficient. In iron deficiency the intra-erythrocytic ZPP concentration is increased. The aim of this study was to investigate whether ZPP is influenced by increased iron levels in hereditary hemochromatosis (HE) and is useful in the clarification of hyperferritinemia. Twenty HE patients and 160 patients with hyperferritinemic caused by anemia of chronic disorders, liver diseases, transfusional iron overload and hematologic or solid malignancies were enrolled. ZPP was measured using the Aviv front-face hematofluorometer (normal <or= 40 micromol/mol heme). In HE, ZPP was significantly lower (median, 20 micromol/mol heme; p = 0.0005) compared to our historical control group. At diagnosis, 15 (75%) HE patients had ZPP values <or=25 micromol/mol heme. After phlebotomy, ZPP remained unchanged (median, 23 micromol/mol heme), although the initially high ferritin concentration decreased to normal. ZPP values in the other hyperferritinemic groups were significantly higher compared to HE and control groups. In contrast to HE, ZPP values <or=25 micromol/mol heme were only observed in 11% of cases with non-transfusional hyperferritinemia. The diagnostic accuracy of a ZPP <or=25 micromol/mol heme to detect HE in non-transfused hyperferritinemic patients was 87%, with a sensitivity of 75% and a specificity of 89%. Showing significantly lower values in HE, ZPP seems to be a useful parameter in distinguishing HE from other hyperferritinemic disorders as those conditions are generally accompanied by an increased ZPP.
Authors:
Georgia Metzgeroth; Beate Schultheis; Alexandra Dorn-Beineke; Rüdiger Hehlmann; Jan Hastka
Related Documents :
19668928 - Prenatal multiple micronutrient supplementation impact on biochemical indicators during...
1565358 - Pregnancy complicated by hereditary spherocytosis.
1679648 - The consequences of iron overdose and its treatment with desferrioxamine in pregnancy.
12192228 - Maternal vitamin use and reduced risk of neuroblastoma.
8473528 - Repeated social stress during pregnancy impairs neuromotor development of the primate i...
641468 - Limited patient knowledge as a reproductive risk factor.
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-02-28
Journal Detail:
Title:  Annals of hematology     Volume:  86     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-03-21     Completed Date:  2007-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Affiliation:
III. Medizinische Universitätsklinik Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Mannheim, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anemia / blood,  diagnosis*
Diagnosis, Differential
Erythrocytes / chemistry,  metabolism*
Female
Ferritins / blood*,  metabolism
Hemochromatosis / blood,  diagnosis*
Humans
Male
Middle Aged
Protoporphyrins / blood*
Chemical
Reg. No./Substance:
0/Protoporphyrins; 15442-64-5/zinc protoporphyrin; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Functional outcome after lengthening with and without deformity correction in polio patients.
Next Document:  Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stabili...