| Zinc preserves an inherent capacity for human sperm chromatin decondensation. | |
| | |
MedLine Citation:
|
PMID: 3925724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effect of zinc on the nuclear chromatin decondensation ability of human, ejaculated spermatozoa was studied by exposing washed spermatozoa to the detergent sodium dodecyl sulphate (SDS) before and after sperm storage. Treatment with EDTA increased the proportion of decondensing spermatozoa before storage. Zinc supplementation before storage reversibly inhibited spontaneous decondensation as well as EDTA-enhanced decondensation. Treatment with EDTA before storage decreased the proportion of spermatozoa decondensing after storage. Zinc supplementation during storage reduced the decrease in the proportion of spermatozoa decondensing after storage. Two effects of zinc were observed: one immediate effect (reversible inhibition of the decondensation) and one long-term effect (protection of the intrinsic capacity for decondensation during storage). Both effects may be explained by a zinc-thiol interaction in the chromatin. Spermatozoal zinc is suggested to protect an inherent capacity for decondensation, thereby helping to extend the functional life-span of the ejaculated spermatozoon. |
| | |
Authors:
|
U Kvist; L Björndahl |
Related Documents
:
|
15117904 - Full-term pregnancies achieved with icsi despite high levels of sperm chromatin damage. 8420504 - Acrosome-reacted sperm in infertile and fertile men using the triple-stain technique. 11897904 - Surgical sperm retrieval: a review of current practice. 15243004 - Influence of the number of motile spermatozoa inseminated and of their morphology on th... 17572244 - Outcome of pregnancy in women with congenital heart disease: a literature review. 11777524 - Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therape... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta physiologica Scandinavica Volume: 124 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1985 Jun |
Date Detail:
|
Created Date: 1985-07-31 Completed Date: 1985-07-31 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
|
Languages: eng Pagination: 195-200 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromatin
/
drug effects* Edetic Acid / pharmacology Ejaculation Humans Male Sodium Dodecyl Sulfate / pharmacology Sperm Capacitation / drug effects* Spermatozoa / drug effects* Time Factors Zinc / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Chromatin; 151-21-3/Sodium Dodecyl Sulfate; 60-00-4/Edetic Acid; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Loss of an intrinsic capacity for human sperm chromatin decondensation.
Next Document: Intracellular Ca2+ buffering potentiates an 86Rb+ permeability response in human lymphocytes.