| Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis. | |
| | |
MedLine Citation:
|
PMID: 21834944 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Reduced collagen matrix in the dermis constitutes one of the characteristic features of chronologically aged skin, which is further enhanced on the sun-exposed portions of the body by chronic ultraviolet light (UV) irradiation, inducing the unique changes associated with skin photoageing. The zinc salt of l-pyrrolidone carboxylate (Zinc PCA) has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. In the present study, by employing cultured normal human dermal fibroblasts, we found that Zinc PCA suppressed UVA-induced activation of activator protein-1 (AP-1) and reduced matrix metalloproteinase-1 production in these cells, which is thought to be involved in collagen degradation in photoaged skin. Moreover, Zinc PCA treatment of the cells increased the expression of an ascorbic acid transporter mRNA, SVCT2, but not SVCT1, resulting in the enhanced production of type I collagen. Based on these in vitro findings, we consider Zinc PCA to be a promising candidate for an anti-skin ageing agent. |
| | |
Authors:
|
Y Takino; F Okura; M Kitazawa; K Iwasaki; H Tagami |
Related Documents
:
|
23324544 - Microscopic observation of symbiotic and aposymbiotic juvenile corals in nutrient-enric... 22527094 - Human pericyte-endothelial cell interactions in co-culture models mimicking the diabeti... 22880114 - Rat bone marrow-derived schwann-like cells differentiated by the optimal inducers combi... 23244894 - 60 the effect of l-ascorbic acid during culture, cryopreservation, or both on porcine e... 1603264 - Inhibition of transporter mediated gamma-aminobutyric acid (gaba) release by skf 89976-... 18031604 - Antioxidant properties of berberine on cultured rabbit corpus cavernosum smooth muscle ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-11 |
Journal Detail:
|
Title: International journal of cosmetic science Volume: - ISSN: 1468-2494 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8007161 Medline TA: Int J Cosmet Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors. ICS © Society of Cosmetic Scientists and the Société Française de Cosmétologie. |
Affiliation:
|
Ajinomoto Co., Inc., Research Institute for Bioscience Products & Fine Chemicals, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681 Ajinomoto Co., Inc., Institute for Innovation, 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi 210-8681 Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of a semi-permanent mascara technology.
Next Document: Effect of leukotriene inhibitors on evolution of experimental brain contusions.