Document Detail

Zinc and immunoresistance to infection in aging: new biological tools.
MedLine Citation:
PMID:  10838605     Owner:  NLM     Status:  MEDLINE    
Infections can cause mortality when the immune system is damaged. The catalytic, structural (in zinc-finger proteins) and regulatory roles of zinc mean that this ion is involved in the maintenance of an effective immune response. Both zinc deficiency and impaired cell-mediated immunity combine during aging to result in increased susceptibility to infection. Dietary supplementation with the recommended daily allowance of zinc for between one and two months decreases the incidence of infection and increases the survival rate following infection in the elderly. This article reviews the biochemical pathways through which zinc might act to increase immunoresistance to infection in the elderly.
E Mocchegiani; M Muzzioli; R Giacconi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  21     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Immunology Centre, Research Department 'Nino Masera', Italian National Research Centres on Aging (I.N.R.C.A.), Via Birarelli 8, 60121, Ancona, Italy.
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MeSH Terms
Aging / immunology*
Immunity / drug effects,  physiology*
Zinc / pharmacology,  physiology*
Zinc Fingers / physiology
Reg. No./Substance:
Comment In:
Trends Pharmacol Sci. 2001 Mar;22(3):112-3   [PMID:  11239569 ]

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