Document Detail

Zinc and immunoresistance to infection in aging: new biological tools.
MedLine Citation:
PMID:  10838605     Owner:  NLM     Status:  MEDLINE    
Infections can cause mortality when the immune system is damaged. The catalytic, structural (in zinc-finger proteins) and regulatory roles of zinc mean that this ion is involved in the maintenance of an effective immune response. Both zinc deficiency and impaired cell-mediated immunity combine during aging to result in increased susceptibility to infection. Dietary supplementation with the recommended daily allowance of zinc for between one and two months decreases the incidence of infection and increases the survival rate following infection in the elderly. This article reviews the biochemical pathways through which zinc might act to increase immunoresistance to infection in the elderly.
E Mocchegiani; M Muzzioli; R Giacconi
Related Documents :
21553315 - Current microbiology of percutaneous endoscopic gastrostomy tube (peg tube) insertion s...
19740885 - Seasonality and comparative dynamics of six childhood infections in pre-vaccination cop...
3034305 - Primary hepatitis a virus infection in developing countries: decline of maternal antibo...
11711625 - A human herpesvirus 7 glycoprotein, u21, diverts major histocompatibility complex class...
23236915 - Sex-specific effects of an avian malaria parasite on an insect vector: support for the ...
17542645 - Primary involvement of pharynx and peyer's patch in inhalational and intestinal anthrax.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  21     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Immunology Centre, Research Department 'Nino Masera', Italian National Research Centres on Aging (I.N.R.C.A.), Via Birarelli 8, 60121, Ancona, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aging / immunology*
Immunity / drug effects,  physiology*
Zinc / pharmacology,  physiology*
Zinc Fingers / physiology
Reg. No./Substance:
Comment In:
Trends Pharmacol Sci. 2001 Mar;22(3):112-3   [PMID:  11239569 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Arbitrary associations between antecedents and actions.
Next Document:  Nicotinic receptor function: new perspectives from knockout mice.