Document Detail


Zinc distribution in blood components, inflammatory status, and clinical indexes of disease activity during zinc supplementation in inflammatory rheumatic diseases.
MedLine Citation:
PMID:  8480688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of zinc supplementation on zinc status and on clinical and biological indicators of inflammation were investigated in 18 patients with chronic inflammatory rheumatic diseases and in 9 healthy control subjects. Patients with mild and recent onset disease were assigned to a 60-d trial to receive either 45 mg Zn (as gluconate)/d or a placebo, while control subjects received the zinc supplement. Baseline mean plasma zinc of the patients was low whereas mononuclear cell zinc content was elevated, suggesting a redistribution of the element related to the inflammatory process rather than to a zinc-deficient state. Zinc supplementation increased plasma zinc to a similar extent in patients and in control subjects, which suggested no impairment of zinc intestinal absorption as a result of the inflammatory process. On the contrary, erythrocyte and leukocyte zinc concentrations were not modified in the two groups examined. No beneficial effect of zinc treatment could be demonstrated on either clinical or inflammation indexes.
Authors:
A Peretz; J Nève; O Jeghers; F Pelen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  57     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  690-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Rheumatology--Internal Medicine, Brugmann Hospital, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Inflammation
Leukocytes, Mononuclear / chemistry
Male
Middle Aged
Neutrophils / chemistry
Nutritional Status
Rheumatic Diseases / blood,  drug therapy*,  physiopathology
Zinc / analysis,  pharmacokinetics*,  therapeutic use*
Chemical
Reg. No./Substance:
7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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