Document Detail

Zinc-deficient rats have fewer recent thymic emigrant (CD90+) T lymphocytes in spleen and blood.
MedLine Citation:
PMID:  14652378     Owner:  NLM     Status:  MEDLINE    
It has been hypothesized that increased expression of the signaling protein p56(lck) disrupts maturation of T lymphocytes, leading to the lymphopenia associated with dietary zinc deficiency and malnutrition. Our objective was to examine p56(lck) protein levels, flow cytometric markers of T cell development (CD4, CD8, TCRalphabeta, TCRgammadelta and CD90) and absolute cell numbers in thymus, spleen and blood of zinc-deficient (ZD), diet-restricted (DR) and control (CTL) rats. Recent thymic emigrant (CD90+) T lymphocytes were also investigated after dietary repletion. P56(lck) protein levels were one- to twofold greater in thymocytes than splenocytes, and ZD rats had more thymocyte p56(lck) protein than CTL rats. In the thymus and blood, the proportions of T lymphocyte subpopulations (CD4-CD8-, CD4+CD8+ and CD4+CD- or CD4-CD8+) were unchanged, except for a higher percentage of TCRalphabeta+CD-CD8+ thymocytes in ZD rats. The 15-29% fewer CD90+ T cells in the blood and spleen of ZD rats were reversed after dietary repletion for 7 and 23 d, respectively. In summary, T-cell numbers were proportional to thymus and spleen weights and unaltered per unit blood volume, despite elevated thymocyte p56(lck) protein in ZD rats. In zinc deficiency, the decreased percentages of CD90+ cells in the blood and spleen could adversely affect the T-cell repertoire.
Heather J Hosea; Edward S Rector; Carla G Taylor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-01-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4239-42     Citation Subset:  IM    
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2.
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MeSH Terms
Antigens, Thy-1 / metabolism*
Blood Cells / cytology,  metabolism*
Cell Count
Cell Movement
Lymphocyte Count
Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / metabolism
Rats, Sprague-Dawley
Spleen / cytology*,  metabolism*
T-Lymphocyte Subsets / cytology,  metabolism
T-Lymphocytes / cytology,  metabolism*,  physiology
Thymus Gland / cytology
Zinc / deficiency*
Reg. No./Substance:
0/Antigens, Thy-1; 7440-66-6/Zinc; EC Specific Protein Tyrosine Kinase p56(lck)

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