Document Detail


Zinc, copper, and superoxide dismutase in hepatocellular carcinoma.
MedLine Citation:
PMID:  9399766     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Superoxide dismutase (Cu/Zn), a metalloenzyme, activity was found to be significantly lower in the human hepatocellular carcinoma (hepatoma tissue) (0.78 +/- 0.33 U/microg protein) compared with that seen in the surrounding "normal" or cirrhotic tissue (1.40 +/- 0.48 U/microg; 1.27 +/- 0.64 U/microg). The SOD activity of "normal" appearing liver cells adjacent to the tumor or cirrhotic tissue is still lower than that level observed in the normal liver from the subjects without known liver disease (1.40 +/- 0.48 U/microg vs 2.94 +/- 1.53 U/microg). We have also observed that the trace elements of zinc and copper, which are essential in expressing the enzyme activity are also significantly lower in the hepatoma (22.54 +/- 6.73 microg and 2.83 +/- 1.16 microg per gram of tissue) compared with those in the surrounding "normal" hepatic tissue (Zn2+, 64.36 +/- 9.17 microg/g; Cu2+, 11.43 +/- 4.74 microg/g). The difference in the zinc content between the "normal" and the cirrhotic tissue is also significant (64.36 +/- 9.17 microg/g vs 42.37 +/- 10.97 microg/g). However, the copper content in the cirrhotic tissue is higher but not statistically different from that level in the "normal" tissue (15.53 +/- 5.90 microg/g vs 11.43 +/- 4.74 microg/g). Furthermore, the plasma zinc level is significantly lower among the patients who have suffered from hepatoma compared with those subjects without known liver disease (631.73 +/- 52.43 microg/L vs 845.53 +/- 68.13 microg/L). Our data suggest that the superoxide dismutase activity is impaired in the hepatoma tissue. The lower concentration of trace elements (Zn2+ and Cu2+) found in the hepatoma tissue may contribute to cause the difference in the observed enzymic activities.
Authors:
K Y Liaw; P H Lee; F C Wu; J S Tsai; S Y Lin-Shiau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1997-12-29     Completed Date:  1997-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2260-3     Citation Subset:  IM    
Affiliation:
Department of Surgery and Institute of Pharmacology, College of Medicine, National Taiwan University Hospital, Taipei, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Hepatocellular / blood,  chemistry*,  enzymology,  pathology
Copper / analysis*
Female
Humans
Liver / chemistry,  pathology
Liver Cirrhosis / metabolism,  pathology
Liver Neoplasms / blood,  chemistry*,  enzymology,  pathology
Male
Middle Aged
Mitochondria, Liver / enzymology
Proteins / analysis
Superoxide Dismutase / analysis*
Trace Elements / analysis,  blood
Zinc / analysis*,  blood
Chemical
Reg. No./Substance:
0/Proteins; 0/Trace Elements; 7440-50-8/Copper; 7440-66-6/Zinc; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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