Document Detail

Zinc, copper, selenium and manganese blood levels in preterm infants.
MedLine Citation:
PMID:  17468128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To measure the zinc, copper, selenium and manganese blood levels in a cohort of 68 preterm infants, and to establish any associations with growth and/or dietary intake.
DESIGN: Blood samples were collected at an infant's expected date of delivery (term) and 6 months later. Serum zinc, plasma copper and whole blood manganese were analysed by atomic absorption spectrometry, plasma and red cell selenium were determined by mass spectrometry. Growth and dietary intake determinations have been previously published.
SETTING: Hampshire, England.
RESULTS: Mean (SD) birth weight of the infants was 1.47 (0.434) kg and mean gestation was 31.4 (2.9) weeks. Mean blood levels at term and 6 months were: serum zinc 12.0 (2.6) micromol/l and 13.8 (2.5) micromol/l; plasma copper 10.1 (2.6) micromol/l and 19.2 (3.6) micromol/l; plasma selenium 0.49 (0.15) micromol/l and 0.72 (0.14) micromol/l; red blood cell selenium 1.68 (0.40) micromol/l and 1.33 (0.19) micromol/l; and blood manganese 320 (189) nmol/l and 211 (68) nmol/l, respectively. There were no significant associations between levels of zinc and copper and dietary intakes of those nutrients at either age (dietary intakes of selenium and manganese were not determined). Only copper levels at term were significantly associated (r = 0.31; p = 0.05) with a growth parameter (head circumference).
CONCLUSION: These results provide new information about trace element status in this vulnerable population.
Lynne D Marriott; Keith D Foote; Alan C Kimber; H Trevor Delves; Jane B Morgan
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Publication Detail:
Type:  Journal Article     Date:  2007-04-27
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  92     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F494-7     Citation Subset:  AIM; IM    
MRC Epidemiology Resource Centre, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK.
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MeSH Terms
Child Development*
Copper / blood
Great Britain
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature / growth & development,  physiology*
Longitudinal Studies
Manganese / blood
Selenium / blood
Trace Elements / blood*
Zinc / blood
Reg. No./Substance:
0/Trace Elements; 7439-96-5/Manganese; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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