Document Detail

Zinc, copper, and iron metabolism during porcine fetal development.
MedLine Citation:
PMID:  10383097     Owner:  NLM     Status:  MEDLINE    
Zinc, copper, and iron levels in maternal and fetal pig tissues and fluids were measured starting on d 30 of gestation and continuing to term (d 114) at 10-d intervals. Fetal hematocrit increased from a low of 19% on d 30 to 32% by d 50, after which it remained above 30% to term. Amniotic fluid zinc, copper, and iron all reached maximal levels by d 60 of gestation. Maternal serum zinc levels fluctuated little during gestation, but fetal serum zinc concentration was significantly elevated above maternal levels during the second trimester. Fetal serum copper levels were significantly lower than maternal values throughout gestation and this was also the case for ceruloplasmin oxidase activity. Maternal serum iron reached its lowest level by d 80 of gestation when rate of transfer of iron to the developing fetuses was high. Fetal serum iron declined throughout gestation, reaching its lowest level on d 100. In general, fetal liver concentrations of zinc, copper, and iron were higher than the corresponding maternal values throughout gestation. Distinct increases were noted for fetal hepatic zinc and copper concentrations during the second trimester of pregnancy and these were accompanied by increases in cytosolic and metallothionein-bound zinc and copper levels. Maternal hepatic iron declined during the second trimester, reaching its lowest point on d 80, indicative of the shunting of maternal iron reserves to fetal tissues. Fetal kidney metal levels did not demonstrate any distinctive developmental patterns with respect to zinc, copper, or iron concentrations, but a general accumulation of each metal was observed as gestation progressed. The results of this study highlight some of the distinct changes occurring in the metabolism of zinc, copper, and iron in both maternal and fetal tissues and fluids during gestation in the pig.
M P Richards
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  69     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-03     Completed Date:  1999-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  27-44     Citation Subset:  IM    
U.S. Department of Agriculture, Agricultural Research Service, Livestock and Poultry Sciences Institute, Growth Biology Laboratory, Beltsville, MD 20705, USA.
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MeSH Terms
Body Weight
Copper / blood,  metabolism*,  pharmacokinetics
Embryonic and Fetal Development*
Iron / blood,  metabolism*,  pharmacokinetics
Kidney / embryology,  metabolism
Liver / embryology,  metabolism
Maternal-Fetal Exchange
Tissue Distribution
Zinc / blood,  metabolism*,  pharmacokinetics
Reg. No./Substance:
7439-89-6/Iron; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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