Document Detail


Zinc and copper in infants fed breast-milk or different formula.
MedLine Citation:
PMID:  7813538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 129 term infants at birth and at the age of 4 months, zinc and copper concentrations of plasma and urine were determined by graphite furnace atomic absorption spectrophotometry and the values correlated to other biochemical parameters and somatic data. Of the infants, 49 were exclusively breast-fed, 44 fed with various commercially available cow's milk formula, 35 fed with a hypoallergenic formula (cows's milk whey hydrolysate, commercially available, supplemented with zinc and copper). Plasma zinc values declined from birth to the age of 4 months in all three groups (P < 0.001). In formula fed children, 4 months old, the values (11.1 +/- 1.7 mumol Zn/l) were significantly lower than in breast-fed (12.2 +/- 1.7 mumol Zn/l; P = 0.004) or babies on hypo-allergenic formula (12.4 +/- 1.6 mumol Zn/l; P = 0.0015). In accordance with the literature plasma copper and caeruloplasmin values increased significantly within the first 4 months of life, the plasma levels were similar in either feeding group, only urinary copper excretion was higher in male infants on hypo-allergenic formula (P < 0.03) at the age of 4 months. There were no correlations between zinc or copper values and alkaline phosphatase. In infants on hypo-allergenic formula there was a negative correlation between plasma zinc and weight or height increments. Despite different zinc and copper supply, presumedly different bioavailability, and different plasma zinc values, all infants thrived and weight and length increments were similar in each group.
Authors:
I Lombeck; A Fuchs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study    
Journal Detail:
Title:  European journal of pediatrics     Volume:  153     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-08     Completed Date:  1995-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  770-6     Citation Subset:  IM    
Affiliation:
Universitäts-Kinderkrankenhaus, Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Body Height
Body Weight
Copper / administration & dosage,  blood*,  urine
Female
Humans
Infant Food / analysis*
Infant, Newborn
Male
Milk, Human / chemistry*
Nutritional Status*
Zinc / administration & dosage,  blood*,  urine
Chemical
Reg. No./Substance:
7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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