Document Detail

Zinc, copper, and blood pressure: Human population studies.
Jump to Full Text
MedLine Citation:
PMID:  23291705     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Copper and zinc are essential trace biometals that regulate cardiovascular homeostasis, and dysregulation of these metals has been linked to vascular diseases, including hypertension. In this article, we review recent human population studies concerning this topic, focusing on: 1) the relationship between blood pressure and levels of zinc and copper; 2) correlations between trace metals, the renin-angiotensin system, obesity, and hypertension; 3) the relationship between environmental metal pollution and the development of hypertension; and 4) methods commonly employed to assay zinc and copper in human specimens. Moreover, based on the findings of these studies, we suggest the following topics as the basis for future investigations: 1) the potential role of environmental metal pollution as a causal factor for hypertension; 2) metal profiles within specific pathogenic subsets of patients with hypertension; 3) standardizing the experimental design so that the results between different studies are more comparable; and 4) the requirement for animal experiments as complementary approaches to address mechanistic insight that cannot be studied in human populations.
William E Carpenter; Derek Lam; Glenn M Toney; Neal L Weintraub; Zhenyu Qin
Related Documents :
16275455 - Noninvasive measurement of aortic aneurysm sac tension with vibrometry.
22948895 - Polymorphisms in endothelial nitric oxide synthase (enos) and vascular endothelial grow...
3724215 - The mechanism of spinal cord injury after simple and double aortic cross-clamping.
17066325 - Biomechanics of the porcine basilar artery in hypertension.
3087125 - Blood gas and hemodynamic changes induced by the treatment of pulmonary congestion with...
20489685 - Relationship of self-reported alcohol consumption to ambulatory blood pressure in a sam...
Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  19     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-01-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Med Sci Monit
Journal ID (iso-abbrev): Med. Sci. Monit
Journal ID (publisher-id): Medical Science Monitor
ISSN: 1234-1010
ISSN: 1643-3750
Publisher: International Scientific Literature, Inc.
Article Information
Download PDF
© Med Sci Monit, 2013
Received Day: 02 Month: 7 Year: 2012
Accepted Day: 18 Month: 9 Year: 2012
collection publication date: Year: 2013
Electronic publication date: Day: 01 Month: 1 Year: 2013
Volume: 19First Page: 1 Last Page: 8
PubMed Id: 23291705
ID: 3628354
Publisher Id: medscimonit-19-1

Zinc, copper, and blood pressure: Human population studies
William E. Carpenter1
Derek Lam1
Glenn M. Toney2
Neal L. Weintraub3
Zhenyu Qin1
1Division of Vascular Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
2Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX, U.S.A.
3Division of Cardiovascular Disease, Department of Medicine, University of Cincinnati, Cincinnati, OH, U.S.A.
Correspondence: Zhenyu Qin, e-mail:


An estimated 1 billion individuals worldwide have high blood pressure, which is associated with approximately 7.1 million deaths per year [1]. In the United States, at least 50 million individuals are using hypertension treatment [23]. Therefore, the prevention and management of hypertension are major public health challenges [26]. Although a number of important nutritional and metabolic factors for hypertension are identified, including inadequate intake of fruits, vegetables, and potassium; excess sodium (sodium chloride) intake; excess body weight; inadequate physical activity; and excess alcohol intake [79], it is important to recognize that many other factors also play a role in this heterogeneous disorder. One of these factors, in particular, is the influence of essential trace metals, such as copper and zinc, on blood pressure. The involvement of copper and zinc in blood pressure regulation is particularly hinted in the human studies via manipulation of dietary copper and zinc levels. For example, copper deficiency reduces hemoglobin synthesis and leads to anemia [10], and anemia is considered as a contributor to increase cardiac output and blood pressure. Deficiency in zinc intake has been proposed to play a role in blood pressure regulation by altering the taste of salt [10]. Indeed, higher dietary zinc intake results in a better taste acuity for salt in healthy young females [11]. Thus, people with zinc deficiency tend to increase salt intake, which can lead to an increase in blood pressure [10]. It has been posited that an imbalance in the homeostasis of zinc metabolism can lead to high blood pressure [12], while copper deficiency can enhance the vulnerability of the heart and blood vessels [13]. Although these dietary studies imply a relationship between inadequate intake of these metals and high blood pressure, it is important to ask a more direct question whether copper and zinc levels are altered in patients with hypertension. Thus, in this article, we will examine reported correlations between tissue copper and zinc levels and high blood pressure, focusing on recent human population studies. We specifically highlight the challenges in data interpretation and describe gaps in knowledge that should addressed in future investigations. Please note that, in this article, we do not attempt an analysis of the large body of observations now on record regarding the action of these metals in animal models; such a review of zinc metabolism in arterial hypertension has been provided by Tubek [12].

Relationship Between Blood Pressure and Levels of Zinc and Copper

Many studies in humans hint a correlation between zinc and copper levels and hypertension. For example, zinc and the zinc/copper ratio are decreased in hypertensives as compared with normotensives [14,15]. Chiplonkar et al. reported lower erythrocyte membrane zinc in hypertensive compared to normotensive lacto-vegetarians [16]. Suliburska et al. reported lower zinc in hair of obese hypertensives [17]. Olatunbosun found significantly increased serum copper levels in hypertensive patients [18]. In contrast, Taneja and colleagues reported increased serum zinc, and decreased levels of copper, in hypertensives, while urinary levels of both zinc and copper were increased in hypertensives [19]. Ghayour-Mobarhan et al. reported that serum copper is higher in hypertensives [20]. However, de la Sierra A et al. reported that there is no correlation between the degree of endothelial dysfunction and serum copper or zinc levels [21].

It is critical to understand what underlies the discrepancies regarding trends of copper and zinc levels in these studies. First, we should notice that the study design is different between each study. Table 1 compares the differences in design of studies reviewed in this article. As we can see, the differences between each study include (but are not limited to) age, gender ratio, medication status, smoking and alcohol history, and hypertension evaluation procedures. Second, these discrepant results also suggest that the involvement of copper and zinc in hypertension appears far more complicated than is currently understood. Thus, using a global population approach to understand the relationship between trace zinc, copper and hypertension may not be optimal. In this article, we posit that instead of studying the whole hypertensive population, it is more important to investigate the specific pathogenic subsets of patients with hypertension, as indicated in the following sections.

Renin-Angiotensin System, Metal, and Blood Pressure

One important contributor for the pathogenesis of essential hypertension is the renin-angiotensin system (RAS) [22]. Generally, a decrease in circulating blood volume leads to lowered blood pressure. These circumstances trigger the kidneys to release renin. Mediated by angiotensin converting enzyme (ACE), renin transforms angiotensinogen into angiotensin II. Angiotensin II acts on multiple target organs throughout the body including the brain, promoting the generation of reactive oxygen species [23], vasoconstriction, the adrenal release of aldosterone, and the activation of sympathetic nerve discharge, ultimately increasing circulating volume and blood pressure [24]. Therefore, the levels of renin, ACE, and aldosterone in blood serve as an index of RAS activation. However, whether RAS activation is correlated with trace metal levels in the circulation, cardiovascular tissues and/or anatomic regions of brain is unknown. Tubek [25] studied the correlation between zinc metabolism and the RAS in patients with essential hypertension. This study included 38 patients, 24 men and 14 women, between 16–59 years of age. In women, plasma renin and ACE were negatively correlated to total zinc efflux from lymphocytes; ACE and serum aldosterone were negatively correlated to oubain-dependent zinc efflux from lymphocytes, and all three RAS parameters were positively correlated to lymphocyte zinc levels. In men, the only correlation observed was a positive correlation between aldosterone and serum zinc. With regard to blood pressure, women showed a negative correlation to lymphocyte zinc, serum zinc, oubain-dependent zinc efflux from lymphocytes, and total zinc efflux from lymphocytes. Men had a negative correlation to lymphocyte zinc as well. These results indicate that there are notable gender differences in the relationship between zinc metabolism and the RAS. Also, this study shows a connection between these specific parameters and blood pressure in patients with primary hypertension. The author posited that women with mild hypertension, but not men, exhibit an association between zinc regulation and RAS activation. Determination of the underlying mechanisms for these gender differences and the reasons for the observed correlations will require more focused investigations.

Obesity, Trace Metals, and Blood Pressure

Leptin is predominantly produced by adipocytes, and serum leptin concentration is correlated with obesity [26]. Olusi et al. investigated associations among serum leptin, zinc, copper, and zinc/copper ratio in healthy individuals (n=570; 223 males vs. 347 females; aged 15 yr and older) in the normal Arab population [27]. Interestingly, this study showed that serum leptin was positively associated with serum copper, but negatively associated with the zinc/copper ratio, while there was no significant association between serum leptin and zinc [27]. Because leptin can also induce sodium retention and systemic vasoconstriction leading to an elevation in blood pressure [28], it is considered to be a contributing factor in essential hypertension. Canatan et al. [14] investigated plasma levels of leptin, zinc and copper in primary essential hypertensives (n=35; 18 female vs. 17 male) and healthy normotensives (n=50; 28 female vs. 22 male). The authors reported a negative correlation between leptin and zinc as well as leptin and the zinc/copper ratio; in obese patients with primary hypertension, leptin levels were increased, zinc and zinc/copper ratio were decreased. However, copper alone did not show significant correlation with leptin in this study [14]. Because obesity contributes to increased blood pressure in most patients with essential hypertension, which appears to be mediated in part by increased levels of leptin [29], the population study by Canaton et al. suggests an interesting link between copper, zinc, and leptin in obesity. The role of trace metals in regulating leptin function and metabolism, and the mechanistic basis for the observed correlations, are deserving of further investigation.

Environmental Metal Pollution and Blood Pressure

Environmental factors, such as diet, physical activity, and water and air pollution, affect the development of cardiovascular disease [30]. Iron and copper are two common elements of particulate matter contributing to air pollution. Air pollution is a mixture of gases, liquids, and particulate matter, and there is increasing concern regarding its potential deleterious effects on human health. After being released into the atmosphere (troposphere), pollutants are carried back in rainwater to further generalize environmental pollution. Tubek et al. calculated the yearly average number of hospitalizations caused by certain diseases in the region of Opole Voivodship, Poland [31]. Using rainwater as a monitor for environmental pollution, they investigated the correlation between chemical elements in rainwater and the hospitalization frequency of certain diseases. This study hinted a mild correlation between zinc and cadmium levels and hospitalizations for hypertension. The authors also posited that absorption of zinc through the lungs is a contributing factor, because ACE is highly localized to lung and requires zinc for its activity [31].

Chandigarh is a city with high occurrence of hypertension in India. Interestingly, in this city, zinc concentrations are higher in vegetables (reddish, turnip, and carrot) irrigated with underground water (120 mg/kg diet) compared with vegetables irrigated with surface water (40 mg/kg diet), while the copper concentrations are not different. Taneja et al. [19] measured dietary intake of zinc and copper in the hypertensive (n=250) and normotensive (n=250) men in this city. This study revealed a positive correlation between serum zinc and blood pressure, and a negative correlation between copper and blood pressure. There was also a positive correlation between urinary zinc and copper and blood pressure. Thus, increased intake of zinc seems to correlate with the increased prevalence of hypertension in Chandigarh, hinting that a dietary-derived disturbance of metal homeostasis might be an important factor contributing to primary hypertension. Moreover, it is notable that soft water areas have a 10–15% higher rate in cardiovascular disease mortality than the areas with medium hardness in water [32].

Methods Commonly Employed to Assay Zinc and Copper in Human Specimens

Several methods have been applied to assay trace metals in human studies. First, the metal concentration can be measured in plasma [14], serum [19], urine [19], and hair or fingernail specimens [33]. These methods are commonly employed because the samples are easily collected. Tooth has also been used in one study [34]. The turnout rate of trace metals in the blood and urine is rapid; whereas the hair, fingernail and tooth accumulate these elements over a long period. Tang et al. reported metal contents in human serum, hair, and fingernails between aged patients with hypertension and coronary heart disease (diseased group) versus aged healthy controls (healthy group) [33]. The zinc content and Zn/Cu ratio in serum of the diseased group were significantly higher than that of the healthy group. Conversely, the zinc content in the hair and fingernails, and Zn/Cu ratio in the hair, of the diseased group were significantly lower than that of the healthy group. Thus, the source of biological material for copper and zinc content analysis must be taken into account when comparing results from different clinical studies.

However, the limitations of these measurements are that they only provide information about trace metals at the tissue levels. Thus, several complementary methodologies have been devised to measure metal concentrations and efflux in blood cells, such as lymphocytes [25] and erythrocytes [35]. For example, in order to measure zinc efflux from lymphocytes, the cells are first incubated with zinc chloride to increase cellular zinc content. Then, the cells are treated with medium free of zinc chloride to determine time-dependent zinc release, which is used to calculate the efflux rate coefficient (ERC). Alternatively, metal content within the erythrocyte membranes can be measured [16,36], which is considered as a more sensitive measurement of zinc [16].

Another way to study metal metabolism in humans is to record their dietary intake of metal, because dietary patterns play an important role in the pathogenesis of many diseases [37], including hypertension. By conducting a food frequency questionnaire documenting specific quantities of food items consumed throughout the year, an estimate of the average daily intake of nutrients and metals can be determined [16]. Dietary metal intake varies from one population to the next due to the wide variations of diet around the world. Thus, it is not uncommon for certain communities to be exposed to different levels of metals due to different life styles and environmental conditions. For example, the traditional Indian diet, known as the lacto-vegetarian diet, consists of high levels of fiber and minerals and reduced fat content. Recently, Chiplonkar et al. [16] determined whether there was an association between dietary metal intake and hypertension in Indian lacto-vegetarians. The authors compared normotensives (n=115; 30 female vs. 85 male) with hypertensives (n=109; 26 female vs. 83 male). This study showed that copper intake was significantly lower in hypertensive compared with normotensive subjects. In addition, erythrocyte membrane zinc was negatively associated with systolic blood pressure.

Table 2 summarizes the representative methods and reference values for each metabolic parameter discussed above. It should be noted that atomic absorption spectrometry (AAS) is widely applied in human populations, presumably due to its lower cost. However, AAS only can detect one element in a single analysis of biological samples. There are several new techniques with multielemental capability, such as inductively coupled plasma mass spectrometry and synchrotron radiation X-ray fluorescence spectrometry, as recently reviewed [38,39]. Finally, the activity and expression of copper containing enzymes might also provide supplemental information about copper status in humans (see review by Danzeisen et al. [40]).

Suggestions and Future Directions

Many human population studies suggest a relationship between copper, zinc and hypertension, although currently we cannot distinguish between causality and association. It is also not surprising that some results are apparently contradictory. In addition to the differences in experimental design between different population studies, the contradictory results also suggest that the relationship between copper, zinc and hypertension is highly complex; depending on the levels, duration of exposure, geographic location, and other preconditions, either promotion of or protection against hypertension is possible. Therefore, more studies are required to definitively establish their roles. Our following suggestions may be helpful.

  1. Involvement of environmental metal pollution in the prevalence of hypertension. Chandigarh is a major city with high prevalence of hypertension; the study by Taneja et al. [19] hints that excess absorption and retention of zinc are common in the population of this city suffering from essential hypertension. And this is associated with higher zinc level in vegetables irrigated with underground water [19]. This finding raises an important question as to whether or not a long-term environmental metal pollution is a contributing factor for high blood pressure. Note that there is an increased prevalence of hypertension in rural and urban areas of developing countries, such as Sub-Saharan Africa [41]. It might be prudent to investigate the potential relationship between environmental metal pollution and hypertension in such areas.
  2. Determine metal profiles within specific pathogenic subsets of patients with hypertension. Hypertension is a multi-factorial disease that involves complex interactions between genetic and environmental factors. The study by Tubek [25] suggests that it may be of interest to compare metal metabolism between high-renin hypertensive versus low-renin hypertensive patients. The study by Canatan et al. [14] also raises an interesting future direction to study the role and/or mechanism of trace metals in obesity related hypertension.
  3. Standardization of the experimental design so that the results between different studies are more comparable. The divergent results observed in human population studies that attempt to correlate metal concentrations with hypertension likely reflect a combination of factors. Amongst these factors, differences in experimental design probably play a role (Table 1). Therefore, to compare the results obtained by different groups, it is necessary to use similar experimental designs. Such standardized experimental designs should include a well accepted and well controlled approach to determine blood pressure and to define hypertension. Moreover, known factors that can influence copper and zinc levels in serum and other samples should be carefully excluded.
  4. The need for animal studies. As an important complementary approach, animal studies should be conducted to address to mechanistic questions that cannot be studied in human populations. Such experiments enable investigators to study normotensive and hypertensive animals of similar genetic backgrounds and body weight in which dietary intake of trace metals can be precisely controlled, thereby leading to more reproducible results and mechanistic insights.


fn1-medscimonit-19-1Source of support: This work was supported by an AHA National Scientist Development Grant (0835268N, ZQ), and by NIH grant HL076684 (NW) and HL62948 (NW). The works of Derek Lam are supported by Voelcker Biomedical Research Academy

AAS atomic absorption spectrometry
ACE angiotensin converting enzyme
RAS renin-angiotensin system

1. WHO, World Health Report 2002Reducing risks, promoting healthy lifeGeneva, SwitzerlandWorld Health Organization
2. Burt VL,et al. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988–1991HypertensionYear: 1995253305137875754
3. Hajjar I,Kotchen TA. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988–2000JamaYear: 2003290219920612851274
4. Qureshi AI,et al. Prevalence and trends of prehypertension and hypertension in United States: National Health and Nutrition Examination Surveys 1976 to 2000Med Sci MonitYear: 2005119CR403916127357
5. Rytlewski K,et al. Leptin and interferon-gamma as possible predictors of cesarean section among women with hypertensive disorders of pregnancyMed Sci MonitYear: 2012188CR50651122847200
6. Mieczkowska J,et al. Effects of cigarette smoking, metabolic syndrome and dehydroepiandrosterone deficiency on intima-media thickness and endothelial function in hypertensive postmenopausal womenMed Sci MonitYear: 2012184CR2253422460094
7. Whelton PK,et al. Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education ProgramJamaYear: 20022881518828812377087
8. Stamler J,et al. Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and womenJamaYear: 19992822120121810591383
9. Guirado GN,et al. Combined exercise training in asymptomatic elderly with controlled hypertension: effects on functional capacity and cardiac diastolic functionMed Sci MonitYear: 2012187CR4616522739737
10. Saltman P. Trace elements and blood pressureAnn Intern MedYear: 1983985 Pt 2823276847020
11. McDaid O,et al. Dietary zinc intake and sex differences in taste acuity in healthy young adultsJ Hum Nutr DietYear: 20072021031017374022
12. Tubek S. Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertensionBiol Trace Elem ResYear: 20071171–3395117873391
13. Uriu-Adams JY,Keen CL. Copper, oxidative stress, and human healthMol Aspects MedYear: 2005264–52689816112185
14. Canatan H,et al. Relationship among levels of leptin and zinc, copper, and zinc/copper ratio in plasma of patients with essential hypertension and healthy normotensive subjectsBiol Trace Elem ResYear: 200410021172315326361
15. Bergomi M,et al. Zinc and copper status and blood pressureJ Trace Elem Med BiolYear: 1997113166699442464
16. Chiplonkar SA,et al. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adultsJ Am Coll NutrYear: 20042332394715190049
17. Suliburska J,et al. Dietary Intake and Serum and Hair Concentrations of Minerals and their Relationship with Serum Lipids and Glucose Levels in Hypertensive and Obese Patients with Insulin ResistanceBiological Trace Element ResearchYear: 201113921375020195917
18. Olatunbosun DA,et al. Relationship of serum copper and zinc to human hypertension in NigeriansBull World Health OrganYear: 1976531134351085664
19. Taneja SK,Mandal R. Mineral factors controlling essential hypertension – a study in the Chandigarh, India populationBiol Trace Elem ResYear: 20071201–3617317916956
20. Ghayour-Mobarhan M,et al. The relationship between established coronary risk factors and serum copper and zinc concentrations in a large Persian CohortJ Trace Elem Med BiolYear: 20092331677519486826
21. de la Sierra A,Larrousse M. Endothelial dysfunction is associated with increased levels of biomarkers in essential hypertensionJ Hum HypertensYear: 20102463737919960026
22. Griendling KK,Murphy TJ,Alexander RW. Molecular biology of the renin-angiotensin systemCirculationYear: 19938761816288389259
23. Mehta PK,Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular systemAm J Physiol Cell PhysiolYear: 20072921C829716870827
24. Qin Z. Newly developed angiotensin II-infused experimental models in vascular biologyRegul PeptYear: 20081501–31618562020
25. Tubek S. Gender differences in selected zinc metabolism parameters in patients with mild primary arterial hypertensionBiol Trace Elem ResYear: 20061141–3556317205987
26. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidenceAnn Intern MedYear: 199913086718010215564
27. Olusi S,et al. Serum copper levels and not zinc are positively associated with serum leptin concentrations in the healthy adult populationBiol Trace Elem ResYear: 20039121374412719608
28. Bravo PE,et al. Leptin and hypertension in obesityVasc Health Risk ManagYear: 2006221636917319461
29. Hall JE,et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortinsJ Biol ChemYear: 201028523172717620348094
30. Brook RD,et al. Air pollution and cardiovascular disease: a statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart AssociationCirculationYear: 20041092126557115173049
31. Tubek S. The content of elements in rainwater and its relation to the frequency of hospitalization for arterial hypertension, chronic obstructive pulmonary disease, and psoriasis in Opole Voivodship, Poland during 2000–2002Biol Trace Elem ResYear: 20081231–32707618273564
32. Pocock SJ,Shaper AG,Packham RF. Studies of water quality and cardiovascular disease in the United KingdomSci Total EnvironYear: 19811825347233165
33. Tang YR,et al. Studies of five microelement contents in human serum, hair, and fingernails correlated with aged hypertension and coronary heart diseaseBiol Trace Elem ResYear: 20039229710412746569
34. Nagaraj G,et al. Tooth element levels indicating exposure profiles in diabetic and hypertensive subjects from Mysore, IndiaBiol Trace Elem ResYear: 200913132556219352596
35. Prasad AS,et al. Experimental zinc deficiency in humansAnn Intern MedYear: 197889448390697227
36. Ruz M,et al. Erythrocytes, erythrocyte membranes, neutrophils and platelets as biopsy materials for the assessment of zinc status in humansBr J NutrYear: 1992682515271445830
37. Tucker KL. Assessment of usual dietary intake in population studies of gene-diet interactionNutr Metab Cardiovasc DisYear: 2007172748117046222
38. Easter RN,et al. Vascular metallomics: copper in the vasculatureVasc MedYear: 2010151616919808712
39. Qin Z,et al. Trace metal imaging with high spatial resolution: applications in biomedicineMetallomicsYear: 201131283721140012
40. Danzeisen R,et al. How reliable and robust are current biomarkers for copper status?Br J NutrYear: 20079846768317666147
41. Edwards R,et al. Hypertension prevalence and care in an urban and rural area of TanzaniaJ HypertensYear: 20001821455210694181

Article Categories:
  • Review Articles

Keywords: copper, zinc, hypertension.

Previous Document:  Transient Hemiparesis (Todd's Paralysis) After Electroconvulsive Therapy (ECT) in a Patient With Maj...
Next Document:  The cytoplasm of living cells behaves as a poroelastic material.