Document Detail

Zinc content in lymphocytes and the activity of zinc ion efflux from lymphocytes in primary arterial hypertension.
MedLine Citation:
PMID:  16217134     Owner:  NLM     Status:  MEDLINE    
Clinical observations and experimental data show that zinc (Zn) plays a role in regulating arterial blood pressure and in arterial hypertension etiopathogenesis. To determine the direction of changes in Zn metabolism in primary arterial hypertension, Zn absorption from the alimentary tract, Zn levels in blood serum, its content in lymphocytes, Zn efflux rate constants from lymphocytes, and urinary Zn excretion in patients with hypertension and in healthy subjects were studied. In this article, Zn levels in blood serum, its content in lymphocytes, and Zn efflux rate constants from lymphocytes are presented. In primary arterial hypertension, on the basis of this study, decreasing Zn levels in blood serum and its decreasing content in lymphocytes were found. The Zn efflux rate constants from lymphocytes increased at the initial stage of hypertension (mild arterial hypertension) and decreased in the late stage of the hypertension disease (severe arterial hypertension). Taking into consideration all of the directions of changes and the fact that Zn can be a factor that increases arterial blood pressure, the changes in Zn distribution can be regarded as having, to a certain extent, a protective character leading to weakening of the pressor reaction, assuming a genetic existence of relative or absolute Zn excess in the body. The changes of Zn distribution can lead, after some time, to Zn deficiency and the resulting metabolic changes (e.g., carbohydrate intolerance).
Slawomir Tubek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  107     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2006-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-99     Citation Subset:  IM    
Faculty of Physical Education and Physiotherapy, Institute of Technology, Opole Clinic of Cardiology, Medical Academy, Wroclaw, Poland.
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MeSH Terms
Case-Control Studies
Hypertension / blood,  metabolism*
Ion Transport
Lymphocytes / metabolism*
Middle Aged
Regression Analysis
Zinc / blood,  metabolism*
Reg. No./Substance:

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