Document Detail

Zinc concentrations during mice gestation.
MedLine Citation:
PMID:  16034165     Owner:  NLM     Status:  MEDLINE    
Severe maternal zinc deficiency has a devastating effect on pregnancy outcome. Studies of humans and experimental animals show that maternal zinc deficiency can cause infertility, prolonged labor, intrauterine growth retardation, teratogenesis, severe immunological deficiencies, or fetal death. The additional need for zinc during pregnancy can be met by an increase in zinc intake. An increase in zinc supplements, when excessive, can cause a decrease in copper. Therefore, it is important to determine the zinc and copper concentrations in embryonic tissue in experimental models and their relationship with embryo number and viability. BALB/c mice were divided into groups according to zinc oral supplementation and gestational age. Phagocytosis was assessed in peritoneal macrophages from dams. The zinc and copper concentrations were obtained by inductively coupled plasma-optical emission spectrometry. Zn and Cu data concentrations in all the analyzed samples were above the detection limits. No spectral interferences were found in both elements. Zinc concentrations show a tendency to increase in embryos (14 gestational days and 21 gestational days) supplemented with zinc. Copper concentrations showed a noticeable tendency to diminish (36% and 27%, respectively) in the same period. In contrast, in placenta Zn values were increased by 30% and Cu values were decreased by 26%. We suggest a pivotal role of the placenta metabolism with its homeostatic mechanisms, in these findings. An important increment appeared in the +Zn embryo number (40%) relative to control (-Zn) embryos at 21 d gestational age. Embryo mortality was at 6% in +Zn embryos and at 20% in -Zn embryos. We consider these findings, both in the number and in the viability of +Zn embryos, outstanding.
Ma Dolores Lastra; Liliana Saldívar; Kristel Martínez; Nadia Munguía; Ciro Márquez; Ana Esther Aguilar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological trace element research     Volume:  105     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-21     Completed Date:  2005-11-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-14     Citation Subset:  IM    
Department of Biology, Immunology Research Lab, Universidad Nacional Autónoma de Mexico, México.
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MeSH Terms
Copper / metabolism
Dietary Supplements
Embryo, Mammalian / metabolism*
Macrophages / metabolism
Mice, Inbred BALB C
Pregnancy, Animal
Spectrophotometry, Atomic
Time Factors
Zinc / deficiency,  metabolism*
Reg. No./Substance:
7440-50-8/Copper; 7440-66-6/Zinc

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