| Zinc coadministration attenuates melatonin's effect on nitric oxide production in mice. | |
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MedLine Citation:
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PMID: 10468163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both melatonin (MEL) and zinc (Zn) are considered beneficial for anti-immunosenescence. MEL's effects on immune functions are partly attributed to an interaction with Zn. However, the augmentation of or interference with MEL's effects by coadministration of Zn remains unclear. In this study, adult older mice received either MEL (10 microg/mL), Zn (22 microg/mL), MEL+Zn, or null supplementation from drinking water for 3 mo. The results showed that treated mice, irrespective of the type of added chemicals, had higher body-weight gain and body-fat content than control mice. MEL- and Zn-treated mice also had increased serum free fatty acid levels. In addition, the MEL group had decreased serum NOx (nitrite+nitrate) values. Serum tumor necrosis factor-alpha levels were increased, although nonsignificantly, in mice that received either MEL or Zn supplementation. However, the differences described were not retained in the mice that received MEL+Zn treatment. We conclude that a high-dose Zn coadministration might exert negative influences on MEL's regulatory effects, at least on nitric oxide production. |
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Authors:
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M D Chen; P Y Lin; W H Sheu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological trace element research Volume: 69 ISSN: 0163-4984 ISO Abbreviation: Biol Trace Elem Res Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-30 Completed Date: 1999-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 261-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Taichung Veterans General Hospital, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects Animals Blood Glucose / metabolism Body Weight / drug effects Fatty Acids, Nonesterified / blood Male Melatonin / administration & dosage, pharmacology* Mice Mice, Inbred C57BL Nitric Oxide / biosynthesis*, blood Triglycerides / blood Tumor Necrosis Factor-alpha / metabolism Zinc / administration & dosage, blood, pharmacology*, urine |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 10102-43-9/Nitric Oxide; 73-31-4/Melatonin; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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