| Zinc, cadmium and nickel increase the activation of NF-κB and the release of cytokines from THP-1 monocytic cells. | |
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MedLine Citation:
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PMID: 21842098 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The sustained activation of the transcription factor nuclear factor κB (NF-κB) by metal-activated signalling pathways can lead to chronic inflammatory processes and related diseases, including carcinogenesis. The aim of the present work was to clarify the effect of zinc, nickel and cadmium on NF-κB activation in the THP-1 human monocytic leukemia cell line. The production of the NF-κB downstream pro-inflammatory mediators tumor necrosis factor (TNF)-α and interleukin (IL)-1β, IL-6 and IL-8 was also evaluated due to their important roles in the pathogenesis of chronic inflammatory and autoimmune diseases and, ultimately, in the development of cancer. The results obtained demonstrated that zinc, nickel and cadmium significantly activate NF-κB, and the release of the chemokine IL-8. Cadmium also induced the release of TNF-α and IL-6 in THP-1 monocytic cells, which may indicate some potential to induce deleterious effects through this pathway. |
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Authors:
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Marisa Freitas; Eduarda Fernandes |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-15 |
Journal Detail:
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Title: Metallomics : integrated biometal science Volume: - ISSN: 1756-591X ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101478346 Medline TA: Metallomics Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4099-030 Porto, Portugal. marisafreitas@ff.up.pt egracas@ff.up.pt. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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