Document Detail


Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase.
MedLine Citation:
PMID:  14581168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system.
Authors:
Toru Egashira; Kumiko Sakai; Fusako Takayama; Mami Sakurai; Satoshi Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  145     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2003-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. takayam@oita-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzoates / chemistry,  pharmacology*
Brain / drug effects,  enzymology
Chromatography, High Pressure Liquid
Haplorhini
Magnetic Resonance Spectroscopy
Male
Mitochondria / drug effects,  enzymology
Monoamine Oxidase / metabolism*
Monoamine Oxidase Inhibitors / chemistry,  pharmacology*
Polystyrenes / chemistry*
Rats
Rats, Wistar
Spectroscopy, Fourier Transform Infrared
Zinc / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/Benzoates; 0/Monoamine Oxidase Inhibitors; 0/Polystyrenes; 7440-66-6/Zinc; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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