| Zinc benzoate, a contaminating environmental compound derived from polystyrene resin inhibits A-type monoamine oxidase. | |
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MedLine Citation:
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PMID: 14581168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. To identify these contaminants, we attempted measurements by HPLC, FT-IR and NMR. The compound inhibiting MAO-A activity was zinc benzoate. Although it potently inhibited MAO-A activity, zinc benzoate did not effect MAO-B in monkey brain mitochondria. It also reversibly and competitively inhibited MAO-A activity in a dose-dependent manner. Zinc benzoate, however, did not inhibit either MAO-A or -B activities in rat brain mitochondria. These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. |
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Authors:
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Toru Egashira; Kumiko Sakai; Fusako Takayama; Mami Sakurai; Satoshi Yoshida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Toxicology letters Volume: 145 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-28 Completed Date: 2003-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 161-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Oita Medical University, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. takayam@oita-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzoates / chemistry, pharmacology* Brain / drug effects, enzymology Chromatography, High Pressure Liquid Haplorhini Magnetic Resonance Spectroscopy Male Mitochondria / drug effects, enzymology Monoamine Oxidase / metabolism* Monoamine Oxidase Inhibitors / chemistry, pharmacology* Polystyrenes / chemistry* Rats Rats, Wistar Spectroscopy, Fourier Transform Infrared Zinc / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Monoamine Oxidase Inhibitors; 0/Polystyrenes; 7440-66-6/Zinc; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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