| Zinc absorption and metabolism by isolated, vascularly perfused rat intestine. | |
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MedLine Citation:
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PMID: 712429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An isolated vascularly perfused rat intestine system was utilized to examine various aspects of zinc absorption in an attempt to more clearly examine the mechanisms involved. The lumen was perfused with a modified tissue culture medium containing 65Zn. The vascular system was perfused from the superior mesenteric artery to the portal vein, with Krebs-Ringer bicarbonate buffer containing 5% rat serum. The criterion for absorption was the amount of radioactivity transferred to the vascular perfusate. When the intestines were obtained from rats that had consumed a zinc-deficient diet the amount of zinc absorbed increased markedly. Conversely, elevation of zinc status decreased the amount of 65Zn that could be transferred to the vascular perfusate. These data strongly suggest that the isolated, perfused rat intestine retains the ability to exercise homeostatic control over 65Zn absorption. Transfer of infused 65Zn to the vascular perfusate was significantly decreased by aspirin, phytate, and prostaglandin E2. Uptake of 65Zn from the lumen into the intestinal cells was significantly increased by histidine and significantly decreased by phytate and prostaglandin E2. Thus, the isolated, vascularly perfused rat intestine appears to be capable of differentiating between the cellular uptake and cell to plasma transfer phases of zinc absorption. |
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Authors:
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K T Smith; R J cousins; B L Silbon; M L Failla |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 108 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-01-15 Completed Date: 1979-01-15 Revised Date: 2005-02-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1849-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Intestinal Absorption* / drug effects Male Perfusion* / methods Rats Zinc / deficiency, metabolism* |
| Chemical | |
Reg. No./Substance:
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7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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