| Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. | |
| | |
MedLine Citation:
|
PMID: 20736941 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: The overproduction of acid and the associated illnesses linked to hypersecretion have a lifetime prevalence of 25-35% in the United States. Although a variety of pharmaceutical agents have been used to reduce the production of acid, alarming new evidence questions the long-term efficacy and safety of the agents. These issues coupled with the delayed onset of action and the return of symptoms in over 60% of the patients is less than satisfactory. The purpose of this study was to determine whether administration of a zinc salt could lead to a rapid and sustained increase in gastric pH in both animals and in humans and provide a new rapid acid suppression therapy. METHODS: Intracellular pH was measured with 2',7'-bis-(2-carboxyethyl)-5-and-6-carboxy-fluorescein in both human and rat gastric glands following an acid load±a secretagogue. In a separate series of studies, whole stomach acid secretion was monitored in rats. A final study used healthy human volunteers while monitoring with a gastric pH measurement received placebo, zinc salt, or a zinc salt and proton pump inhibitor (PPI). RESULTS: We demonstrate that exposure to ZnCl(2) immediately abolished secretagogue-induced acid secretion in isolated human and rat gastric glands, and in intact rat stomachs. Chronic low-dose zinc exposure effectively inhibited acid secretion in whole stomachs and isolated glands. In a randomized cross-over study in 12 volunteers, exposure to a single dose of ZnCl(2) raised intragastric pH for over 3 h, including a fast onset of effect. CONCLUSIONS: Our findings demonstrate that zinc offers a novel rapid and prolonged therapy to inhibit gastric acid secretion in human and rat models. |
| | |
Authors:
|
Philipp Kirchhoff; Thenral Socrates; Shafik Sidani; Andrew Duffy; Tobias Breidthardt; Christian Grob; Carsten T Viehl; Christoph Beglinger; Daniel Oertli; John P Geibel |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-24 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 106 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 62-70 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA. pkirchhoff@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epidemiology of peptic ulcer disease: endoscopic results of the systematic investigation of gastroin...
Next Document: Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high inte...