| Zigzagged augmentation index in diabetes. | |
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MedLine Citation:
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PMID: 20001458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although the patients with diabetic nephropathy suffered high cardiovascular risk, augmentation index (AI) in diabetic nephropathy has been poorly characterized. Cross-sectional studies were performed on 26 diabetic and 27 nondiabetic nephropathic patients. Home blood pressure was examined. In addition, blood pressure, pulse rate, and AI were measured in both supine and sitting positions. Patient backgrounds such as age, sex, sitting blood pressure, and pulse rate were similar between two groups. Circadian variations of home blood pressure were preserved in nondiabetic patients, but disappeared in diabetes. Changing from supine to sitting position induced greater decrements of systolic blood pressure (DeltaSBP -9 +/- 8 mmHg) and AI (DeltaAI -7 +/- 10) in the diabetic group than in nondiabetic patients (DeltaSBP -4 +/- 12 mmHg, DeltaAI -2 +/- 9). Multivariate regression analysis revealed that AI in a sitting position correlated positively to SBP and inversely to pulse rate. Of interest, AI in supine position related positively to age, the presence of diabetes and SBP, and inversely to pulse rate. The present data indicate autonomic dysfunction in patients with diabetic nephropathy. Furthermore, our findings provide the evidence that autonomic dysfunction elicits an inadequate physiological arterial contraction in response to postural change, thereby reducing AI that results in the fall of SBP. Finally, the present results suggest that AI in supine, but not sitting position, is suited for detecting cardiovascular risk in diabetes. |
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Authors:
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Tsuneo Takenaka; Takahiko Sato; Hitoshi Hoshi; Nobutaka Kato; Keita Sueyoshi; Kazuhiro Kobayashi; Hiroshi Takane; Yoshihiko Kanno; Yoichi Ohno; Hiromichi Suzuki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 31 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 657-68 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Faculty of Medicine, Saitama Medical University, 38 Moro-Hongo Moroyama, Iruma, Saitama, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure* Blood Pressure Determination / methods* Blood Pressure Monitoring, Ambulatory / methods Body Mass Index Circadian Rhythm* Cross-Sectional Studies Diabetic Nephropathies / physiopathology* Female Heart Rate Humans Hypertension / complications Kidney Diseases / physiopathology Male Middle Aged Multivariate Analysis Posture Regression Analysis Supine Position* Systole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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