Document Detail


Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer.
MedLine Citation:
PMID:  21216289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.
Authors:
Martha L Peterson; Chunhong Ma; Brett T Spear
Related Documents :
22991089 - Analysis of copy number variations in holstein cows identify potential mechanisms contr...
11867619 - Dual promoter structure of mouse and human fatty acid translocase/cd36 genes and unique...
24036939 - Overexpression of hsa-mir-125b during osteoblastic differentiation does not influence l...
9787179 - Identification of four genes in endothelial cells whose expression is affected by tumor...
1559979 - Concerted evolution of the primate immunoglobulin alpha-gene through gene conversion.
10856919 - Sterol 27-hydroxylase deficiency: a rare cause of xanthomas in normocholesterolemic hum...
7810699 - Potentiated 1,25(oh)2d3-induced 24-hydroxylase gene expression in uremic rat intestine.
2045429 - Long-term expression of gene introduction into normal human t-lymphocytes by retroviral...
25088569 - Transcriptome profile analysis of adipose tissues from fat and short-tailed sheep.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-01-07
Journal Detail:
Title:  Seminars in cancer biology     Volume:  21     ISSN:  1096-3650     ISO Abbreviation:  Semin. Cancer Biol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-06-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9010218     Medline TA:  Semin Cancer Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Microbiology, Immunology & Molecular Genetics and Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Hepatocellular / genetics,  metabolism*
Gene Expression Profiling
Gene Expression Regulation, Neoplastic*
Humans
Liver Neoplasms / genetics,  metabolism*
Microarray Analysis
Transcription Factors / metabolism*
Transcriptional Activation*
alpha-Fetoproteins / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
DK059866/DK/NIDDK NIH HHS; DK074816/DK/NIDDK NIH HHS; R01 DK059866-05/DK/NIDDK NIH HHS; R01 DK074816-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Transcription Factors; 0/alpha-Fetoproteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diurnal rhythm in expression and release of yolk protein in the testis of Spodoptera littoralis (Lep...
Next Document:  Heterologous expression of Translocated promoter region protein, Tpr, identified as a transcription ...