| Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer. | |
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MedLine Citation:
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PMID: 21216289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer. |
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Authors:
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Martha L Peterson; Chunhong Ma; Brett T Spear |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2011-01-07 |
Journal Detail:
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Title: Seminars in cancer biology Volume: 21 ISSN: 1096-3650 ISO Abbreviation: Semin. Cancer Biol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-06-21 Revised Date: 2012-09-18 |
Medline Journal Info:
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Nlm Unique ID: 9010218 Medline TA: Semin Cancer Biol Country: England |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology, Immunology & Molecular Genetics and Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Hepatocellular / genetics, metabolism* Gene Expression Profiling Gene Expression Regulation, Neoplastic* Humans Liver Neoplasms / genetics, metabolism* Microarray Analysis Transcription Factors / metabolism* Transcriptional Activation* alpha-Fetoproteins / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DK059866/DK/NIDDK NIH HHS; DK074816/DK/NIDDK NIH HHS; R01 DK059866-05/DK/NIDDK NIH HHS; R01 DK074816-04/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors; 0/alpha-Fetoproteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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