Document Detail


Zebrafish models in cardiac development and congenital heart birth defects.
MedLine Citation:
PMID:  22704690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The zebrafish has become an ideal vertebrate animal system for investigating cardiac development due to its genetic tractability, external fertilization, early optical clarity and ability to survive without a functional cardiovascular system during development. In particular, recent advances in imaging techniques and the creation of zebrafish transgenics now permit the in vivo analysis of the dynamic cellular events that transpire during cardiac morphogenesis. As a result, the combination of these salient features provides detailed insight as to how specific genes may influence cardiac development at the cellular level. In this review, we will highlight how the zebrafish has been utilized to elucidate not only the underlying mechanisms of cardiac development and human congenital heart diseases (CHDs), but also potential pathways that may modulate cardiac regeneration. Thus, we have organized this review based on the major categories of CHDs-structural heart, functional heart, and vascular/great vessel defects, and will conclude with how the zebrafish may be further used to contribute to our understanding of specific human CHDs in the future.
Authors:
Shu Tu; Neil C Chi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-06-15
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  84     ISSN:  1432-0436     ISO Abbreviation:  Differentiation     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-03     Completed Date:  2012-11-12     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  England    
Other Details:
Languages:  eng     Pagination:  4-16     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Animals
Heart / growth & development,  physiology
Heart Defects, Congenital / genetics*
Humans
Models, Animal*
Molecular Imaging
Organogenesis
Voltage-Sensitive Dye Imaging
Zebrafish / genetics*,  physiology
Grant Support
ID/Acronym/Agency:
DP2 OD007464/OD/NIH HHS; DP2OD07464/OD/NIH HHS; HD069305/HD/NICHD NIH HHS; HL104239/HL/NHLBI NIH HHS; R01 HD069305/HD/NICHD NIH HHS; R01 HL104239/HL/NHLBI NIH HHS
Comments/Corrections

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