Document Detail


Zebrafish cardiac development requires a conserved secondary heart field.
MedLine Citation:
PMID:  21558385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The secondary heart field is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the definitive cardiac arterial pole. This field is part of the overall heart field and its myocardial component has been fate mapped from the epiblast to the heart in both mammals and birds. In this study we show that the population that gives rise to the arterial pole of the zebrafish can be traced from the epiblast, is a discrete part of the mesodermal heart field, and contributes myocardium after initial heart tube formation, giving rise to both smooth muscle and myocardium. We also show that Isl1, a transcription factor associated with undifferentiated cells in the secondary heart field in other species, is active in this field. Furthermore, Bmp signaling promotes myocardial differentiation from the arterial pole progenitor population, whereas inhibiting Smad1/5/8 phosphorylation leads to reduced myocardial differentiation with subsequent increased smooth muscle differentiation. Molecular pathways required for secondary heart field development are conserved in teleosts, as we demonstrate that the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole.
Authors:
Danyal Hami; Adrian C Grimes; Huai-Jen Tsai; Margaret L Kirby
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  138     ISSN:  1477-9129     ISO Abbreviation:  Development     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-07-21     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  2389-98     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Duke University, Durham, NC 27710, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Morphogenetic Proteins / metabolism*
Cell Differentiation
Germ Layers
Heart / embryology*,  growth & development*
Hedgehog Proteins / metabolism
Homeodomain Proteins / metabolism
LIM-Homeodomain Proteins
Muscle Development
Muscle, Smooth / embryology
Myocardium / cytology,  metabolism*
Phosphorylation
Signal Transduction
Smad1 Protein / metabolism
Smad5 Protein / metabolism
Smad8 Protein / metabolism
T-Box Domain Proteins / metabolism
Transcription Factors
Zebrafish / embryology*,  metabolism
Zebrafish Proteins / metabolism
Grant Support
ID/Acronym/Agency:
HL084413/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Bone Morphogenetic Proteins; 0/Hedgehog Proteins; 0/Homeodomain Proteins; 0/LIM-Homeodomain Proteins; 0/Smad1 Protein; 0/Smad5 Protein; 0/Smad8 Protein; 0/T-Box Domain Proteins; 0/Transcription Factors; 0/Zebrafish Proteins; 0/insulin gene enhancer binding protein Isl-1; 0/smad5 protein, zebrafish
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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