Document Detail


Zebrafish Heart Regeneration as a Model for Cardiac Tissue Repair.
MedLine Citation:
PMID:  19081827     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Heart disease remains the leading cause of mortality throughout the world. Mammals have an extremely limited capacity to repair lost or damaged heart tissue, thus encouraging biologists to seek out models for heart regeneration. Zebrafish exhibit a robust regenerative capacity in a variety of tissues including the fin, spinal cord, retina, and heart, making it the sole regenerative vertebrate organism currently amenable to genetic manipulation. Future studies will utilize functional approaches to tease apart zebrafish heart regeneration in hopes of unlocking our own regenerative potential.
Authors:
Robert J Major; Kenneth D Poss
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Drug discovery today. Disease models     Volume:  4     ISSN:  1740-6757     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2009-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235079     Medline TA:  Drug Discov Today Dis Models     Country:  -    
Other Details:
Languages:  ENG     Pagination:  219-225     Citation Subset:  -    
Affiliation:
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 USA.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL081674-03//NHLBI NIH HHS

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