| Zbtb20 Defines a Hippocampal Neuronal Identity Through Direct Repression of Genes That Control Projection Neuron Development in the Isocortex. | |
| | |
MedLine Citation:
|
PMID: 23283686 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Hippocampal pyramidal neurons are important for encoding and retrieval of spatial maps and episodic memories. While previous work has shown that Zbtb20 is a cell fate determinant for CA1 pyramidal neurons, the regulatory mechanisms governing this process are not known. In this study, we demonstrate that Zbtb20 binds to genes that control neuronal subtype specification in the developing isocortex, including Cux1, Cux2, Fezf2, Foxp2, Mef2c, Rorb, Satb2, Sox5, Tbr1, Tle4, and Zfpm2. We show that Zbtb20 represses these genes during ectopic CA1 pyramidal neuron development in transgenic mice. These data reveal a novel regulatory mechanism by which Zbtb20 suppresses the acquisition of an isocortical fate during archicortical neurogenesis to ensure commitment to a CA1 pyramidal neuron fate. We further show that the expression pattern of Zbtb20 is evolutionary conserved in the fetal human hippocampus, where it is complementary to the expression pattern of the Zbtb20 target gene Tbr1. Therefore, the disclosed Zbtb20-mediated transcriptional repressor mechanism may be involved in development of the human archicortex. |
| | |
Authors:
|
Jakob V Nielsen; Mads Thomassen; Kjeld Møllgård; Jens Noraberg; Niels A Jensen |
Related Documents
:
|
23018676 - Neurogenesis and neuronal migration in the forebrain of the torsina knockout mouse embryo. 22593736 - Effect of temperature on spiking patterns of neocortical layer 2/3 and layer 6 pyramida... 15223196 - Subcortical modulation of spatial attention including evidence that the sprague effect ... 12221046 - Electroanatomic mapping and catheter ablation of breakthroughs from the right atrium to... 17049616 - A method of combined single-cell electrophysiology and electroporation. 6641876 - Convergence in the somatosensory pathway between cutaneous afferents from the index and... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
|
Title: Cerebral cortex (New York, N.Y. : 1991) Volume: - ISSN: 1460-2199 ISO Abbreviation: Cereb. Cortex Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, DK-5000 Odense C, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Brain Reactivity Differentiates Subjects with High and Low Dream Recall Frequencies during Both Slee...
Next Document: Connectivity-Based Functional Analysis of Dopamine Release in the Striatum Using Diffusion-Weighted ...