| ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways. | |
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MedLine Citation:
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PMID: 22544323 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts. |
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Authors:
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Tommaso Selmi; Andrea Martello; Tatiana Vignudelli; Erika Ferrari; Alexis Grande; Claudia Gemelli; Paolo Salomoni; Sergio Ferrari; Tommaso Zanocco-Marani |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-15 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 11 ISSN: 1551-4005 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-4-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dipartimento di Scienze Biomediche; Sezione di Chimica Biologica; Università di Modena e Reggio Emilia; Modena, Italy; Samantha Dickson Brain Cancer Unit; UCL Cancer Institute; London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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