Document Detail


ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
MedLine Citation:
PMID:  19362768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.
Authors:
George G Chen; Ursula P F Chan; Long-Chuan Bai; King Yip Fung; Art Tessier; Ann K Y To; Juanita L Merchant; Paul B S Lai
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-11
Journal Detail:
Title:  Cancer letters     Volume:  283     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-18     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  52-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology
Carcinoma, Hepatocellular / metabolism*
Caspase 6 / metabolism*
Cell Cycle / drug effects,  physiology
Cell Death / drug effects,  physiology
Cell Line, Tumor
DNA-Binding Proteins / metabolism*
Flow Cytometry
Fluorouracil / pharmacology
Humans
Liver Neoplasms / metabolism*
S Phase / drug effects,  physiology*
Staurosporine / pharmacology
Transcription Factors / metabolism*
Grant Support
ID/Acronym/Agency:
R01 DK-55732/DK/NIDDK NIH HHS; R01 DK055732/DK/NIDDK NIH HHS; R01 DK055732-08/DK/NIDDK NIH HHS; R01 DK055732-09/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA-Binding Proteins; 0/Transcription Factors; 0/ZNF148 protein, human; EC 3.4.22.-/Caspase 6; H88EPA0A3N/Staurosporine; U3P01618RT/Fluorouracil
Comments/Corrections

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