Document Detail


Z-velocity in screening for intrauterine growth restriction.
MedLine Citation:
PMID:  16254884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Ultrasound scans provide the basis for detection of intrauterine growth restriction (IUGR) but often fail to distinguish IUGR from small-for-gestational age (SGA) fetuses. This study introduces the concept of Z-velocity, calculated as changes in Z-scores over time, as an additional criterion in the diagnosis of IUGR. METHODS: A computer program simulated 50 000 fetal abdominal circumference (FAC) scans based on published growth formulae. False-positive rates were calculated to determine optimal scan time and scan intervals. Using an independent simulation of 32 500 FAC scans, the two methods were compared using receiver-operating characteristics (ROC) curve analysis. RESULTS: ROC showed areas under the curve of > 0.74 over the complete range of scan intervals. The positive predictive value of growth arrest as the only diagnostic criterion was, however, too low to recommend it as an exclusive or the first diagnostic criterion. CONCLUSIONS: Z-velocity can be used to decide whether further investigations for growth abnormality are required in fetuses that fall below the 10(th) percentile. The gain of combined diagnostic approaches should be calculated from large databases that include the neonatal ponderal index as the gold standard.
Authors:
A Mondry; L Pengbo; M Loh; M Mongelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  26     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  634-8     Citation Subset:  IM    
Copyright Information:
(c) 2005 ISUOG
Affiliation:
Bioinformatics Institute, Singapore. mondry@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Diagnosis, Differential
Female
Fetal Growth Retardation / ultrasonography*
Gestational Age
Humans
Infant, Newborn
Infant, Small for Gestational Age*
Predictive Value of Tests
Pregnancy
Reference Values
Sensitivity and Specificity
Ultrasonography, Prenatal / standards*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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