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Z-score mapping method for extracting hypoattenuation areas of hyperacute stroke in unenhanced CT.
MedLine Citation:
PMID:  19734066     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: The purpose of this study was to develop a z-score mapping method on the basis of a voxel-by-voxel analysis to visualize hypoattenuation areas of hyperacute stroke on unenhanced computed tomographic (CT) images. MATERIALS AND METHODS: The algorithm of the developed method consisted of five main steps: anatomic standardization, the construction of a normal reference database, calculation of the z scores, the elimination of false-positive areas, and the extraction of hypoattenuation areas. The obtained z-score map was then superimposed on the original CT images for identifying hypoattenuation areas of hyperacute stroke on the unenhanced CT images. The method was applied to 21 patients with infarctions of the middle cerebral artery territory <3 hours after symptom onset. The performance of the method was evaluated using receiver-operating characteristic analysis. RESULTS: Hypoattenuation regions could be significantly distinguished from normal regions by z-score values (P < .0001). The area under the receiver-operating characteristic curve for distinction between 68 hypoattenuation regions and 142 normal regions was 0.834. CONCLUSIONS: The developed method has the potential to accurately indicate high-signal intensity areas corresponding to hypoattenuation areas on CT images in the hyperacute stage of stroke.
Authors:
Noriyuki Takahashi; Du-Yih Tsai; Yongbum Lee; Toshibumi Kinoshita; Kiyoshi Ishii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-05
Journal Detail:
Title:  Academic radiology     Volume:  17     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-92     Citation Subset:  IM    
Affiliation:
Department of Radiological Technology, Graduate School of Health Sciences, Niigata University, Chuou-ku, Niigata, 951-8518, Japan. b07b401b@mail.cc.niigata-u.ac.jp
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