| Z-321, a prolyl endopeptidase inhibitor, augments the potentiation of synaptic transmission in rat hippocampal slices. | |
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MedLine Citation:
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PMID: 9062687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigated the effects of arginine-vasopressin (AVP) and (1-[3-(2-indanylacetyl)-L-thioprolyl] pyrrolidine (Z-321), an inhibitor of prolyl endopeptidase (PEP; (EC 3.4.21.26)) which degrades AVP in vitro, on the short-lasting potentiation of the field excitatory postsynaptic potentials (EPSP) coupled with a weak tetanus. The EPSP, after the electrical stimulation of the Schaffer collateral/commissural pathway, were recorded in the CA1 region of rat hippocampal slices. AVP at 10(-8) M and Z-321 at 10(-4) M augmented the potentiation induced by the weak tetanus; the magnitude of the post-tetanic potentiation of the EPSP was enhanced and the potentiation lasted for 60 min. In contrast, the racemic D-thioprolyl compound of Z-321, which virtually lacks any inhibitory effects on PEP, failed to affect the potentiation at 10(-4) M. The facilitatory effect of Z-321 was reversed by the application of [d(CH2)5,Tyr(Me)2]AVP (10(-8) M), an antagonist of the AVP V1 receptors, indicating that the effect of Z-321 was mediated through the V1 receptors. These findings suggest that Z-321 augmented the potentiation due to its inhibitory influence on the AVP degradation by PEP. |
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Authors:
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N Miura; S Shibata; S Watanabe |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Behavioural brain research Volume: 83 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-07-09 Completed Date: 1997-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 213-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University 62, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / pharmacology Electric Stimulation Evoked Potentials / drug effects Hippocampus / drug effects* Male Pyrrolidines / pharmacology* Rats Rats, Wistar Serine Endopeptidases / metabolism* Serine Proteinase Inhibitors / pharmacology* Stimulation, Chemical Synaptic Transmission / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/1-(3-(2-indanylacetyl)-L-thioprolyl)pyrrolidine; 0/Pyrrolidines; 0/Serine Proteinase Inhibitors; 113-79-1/Arginine Vasopressin; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.26/prolyl oligopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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