Document Detail


Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project.
MedLine Citation:
PMID:  23198888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average peers. SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults. In additional analyses, some SuperAgers had unusually low densities of age-related Alzheimer pathology and unusually high numbers of von Economo neurons in the anterior cingulate gyrus. SuperAgers were also found to have a lower frequency of the ɛ4 allele of apolipoprotein E than the general population. These preliminary results show that above-average memory capacity can be encountered in advanced age. They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain.
Authors:
Emily J Rogalski; Tamar Gefen; Junzi Shi; Mehrnoosh Samimi; Eileen Bigio; Sandra Weintraub; Changiz Geula; M-Marsel Mesulam
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  25     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-16     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-36     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Aged, 80 and over
Aging / physiology*
Alleles
Apolipoprotein E4 / genetics
Brain / anatomy & histology,  cytology,  pathology,  physiology
Female
Gyrus Cinguli / anatomy & histology,  cytology,  pathology,  physiology
Humans
Magnetic Resonance Imaging
Male
Memory, Episodic*
Middle Aged
Neuropsychological Tests
Grant Support
ID/Acronym/Agency:
AG13854/AG/NIA NIH HHS; P30 AG013854/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein E4
Comments/Corrections

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