| Youthful Memory Capacity in Old Brains: Anatomic and Genetic Clues from the Northwestern SuperAging Project. | |
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MedLine Citation:
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PMID: 23198888 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Northwestern University SuperAging Project recruits community dwellers over the age of 80 who have unusually high performance on tests of episodic memory. In a previous report, a small cohort of SuperAgers was found to have higher cortical thickness on structural MRI than a group of age-matched but cognitively average peers. SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50- to 60-year-old younger cognitively healthy adults. In additional analyses, some SuperAgers had unusually low densities of age-related Alzheimer pathology and unusually high numbers of von Economo neurons in the anterior cingulate gyrus. SuperAgers were also found to have a lower frequency of the ɛ4 allele of apolipoprotein E than the general population. These preliminary results show that above-average memory capacity can be encountered in advanced age. They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain. |
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Authors:
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Emily J Rogalski; Tamar Gefen; Junzi Shi; Mehrnoosh Samimi; Eileen Bigio; Sandra Weintraub; Changiz Geula; M-Marsel Mesulam |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cognitive neuroscience Volume: 25 ISSN: 1530-8898 ISO Abbreviation: J Cogn Neurosci Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910747 Medline TA: J Cogn Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 29-36 Citation Subset: IM |
Affiliation:
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Northwestern University Feinberg School of Medicine, Chicago. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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