Document Detail


Young patients with diminished ovarian reserve undergoing assisted reproductive treatments: a preliminary report.
MedLine Citation:
PMID:  16176667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Young assisted-reproduction patients with diminished ovarian reserve (DOR) are one of the most challenging issues for IVF specialists. A retrospective study of 70 assisted reproduction patients younger than 35 years with DOR determined based on antral follicle count was conducted, investigating: (i) correlation of day 3 FSH measurement with antral follicle count; and (ii) cycle outcome of young DOR patients compared with 53 young assisted reproduction patients with normal ovarian reserve (NR). DOR was considered as antral follicle count of <6 per ovary. Day 3 FSH in the DOR group was significantly higher than in the NR group (8.3 and 6.6 mIU/ml respectively; P < 0.05). Implantation rates between the groups were similar (15% in DOR and 18% in NR). Pregnancy rate was 35.8% in the DOR group, significantly lower than that of the NR group, which was 54.7% (P = 0.028). Although the pregnancy rate was significantly lower in the DOR group compared with the NR group, the statistically insignificant difference in implantation rates demonstrated that the problem in young DOR patients was mainly the number of retrieved oocytes. Therefore, such couples should be informed that lower oocyte numbers will result in statistically lower, but still encouraging, pregnancy rates. Basal FSH should also be measured during evaluation as an adjunct to antral follicle count.
Authors:
Banu Kumbak; Engin Oral; Semra Kahraman; Guvenc Karlikaya; Hale Karagozoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  11     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-22     Completed Date:  2005-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  294-9     Citation Subset:  IM    
Affiliation:
Istanbul Memorial Hospital, ART and Genetics Centre, Istanbul, Turkey. bkumbak@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Cell Count
Embryo Implantation
Female
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / blood*
Humans
Male
Oocytes / physiology
Ovarian Follicle / cytology*
Ovary / physiopathology*
Pregnancy
Pregnancy Rate
Retrospective Studies
Chemical
Reg. No./Substance:
9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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