Document Detail

Young adult-form of dementia with neurofibrillary changes and Lewy bodies.
MedLine Citation:
PMID:  3661124     Owner:  NLM     Status:  MEDLINE    
Alzheimer's neurofibrillary tangles, Lewy bodies and chromatolytic neurons were found in the brain at autopsy of a 28-year-old male with pyramidal and extrapyramidal signs, and severe dementia of 7-year duration prior to his death. Review of histological material showed generalized changes involving both cortical and subcortical structures. These changes were characterized by the presence of neurofibrillary myelin in long tracts and in subcortical regions. The neurofibrillary tangles were mostly composed of Alzheimer's paired helical filaments (PHF), PHF were immunostained with both polyclonal and monoclonal antibodies to PHF and the microtubule-associated protein tau. Some Lewy bodies were immunolabelled with monoclonal antibodies to PHF. To the best of our knowledge it is the first reported case of a young adult-form of dementia with extensive formation of neurofibrillary changes and Lewy bodies.
E R Popovitch; H M Wisniewski; M A Kaufman; I Grundke-Iqbal; G Y Wen
Related Documents :
11619014 - The protagon phoenix.
2766964 - Development of the human hypoglossal nucleus: a morphometric study.
11017844 - Isolation and characterization of adenovirus 5 from the brain of an infant with fatal c...
17692894 - Homo floresiensis and the evolution of the hominin shoulder.
6615234 - Cadmium in finnish breast milk, a longitudinal study.
17589604 - Declines in sex ratio at birth and fetal deaths in japan, and in u.s. whites but not af...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta neuropathologica     Volume:  74     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-27     Completed Date:  1987-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Department of Pathological Neurobiology, New York State Office of Mental Retardation and Developmental Disabilities, Staten Island 10314.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dementia / complications,  pathology*
Mental Retardation / complications*
Microscopy, Electron
Neurofibrils / ultrastructure*
Organoids / ultrastructure
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peculiar pattern of glial fibrillary acidic protein production in extracranial metastatic tumor cell...
Next Document:  Conservative management of the abnormal smear during pregnancy. A long-term follow-up.