Document Detail


The Young Netherlands Twin Register (YNTR): Longitudinal Twin and Family Studies in Over 70,000 Children.
MedLine Citation:
PMID:  23186620     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents.
Authors:
Catharina E M van Beijsterveldt; Maria Groen-Blokhuis; Jouke Jan Hottenga; Sanja Franić; James J Hudziak; Diane Lamb; Charlotte Huppertz; Eveline de Zeeuw; Michel Nivard; Nienke Schutte; Suzanne Swagerman; Tina Glasner; Michelle van Fulpen; Cyrina Brouwer; Therese Stroet; Dustin Nowotny; Erik A Ehli; Gareth E Davies; Paul Scheet; Jacob F Orlebeke; Kees-Jan Kan; Dirk Smit; Conor V Dolan; Christel M Middeldorp; Eco J C de Geus; Meike Bartels; Dorret I Boomsma
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-28
Journal Detail:
Title:  Twin research and human genetics : the official journal of the International Society for Twin Studies     Volume:  -     ISSN:  1832-4274     ISO Abbreviation:  Twin Res Hum Genet     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244624     Medline TA:  Twin Res Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-16     Citation Subset:  -    
Affiliation:
Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
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