Document Detail


Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide.
MedLine Citation:
PMID:  23286212     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. The aim of this post hoc analysis was to establish the relationship between FE(NO) levels and the asthma predictive index (API) among infants with recurrent wheezing. Methods. Infants with recurrent wheezing (three or more episodes) were recruited consecutively and online FE(NO) tests at tidal breathing with multiple breaths were performed. Results. Twenty-seven (84%) out of 32 infants (median age of 12 months) who met the inclusion criteria for this post hoc analysis, successfully performed the FE(NO) determinations. Eighteen (66%) infants were classified with positive stringent API. FE(NO) levels were significantly higher among patients with positive API than those with negative (median [IQR] of 12.3 [14.8] ppb vs. 4.1 [7.9] ppb, respectively, p = .016). Furthermore, FE(NO) and positive API had a significant correlation (Spearman's rho, ρ = 0.4741, p = .0125). After logistic regression analysis including FE(NO) levels, gender, age, and use of controller therapy, FE(NO) was the only variable that was marginally related to API (OR = 1.12, 95% CI: 0.99-1.27, p = .07). Conclusion. Infants with recurrent wheezing who had a positive stringent API already had higher FE(NO) levels than those with a negative API. This finding needs to be corroborated in a larger prospective study.
Authors:
Jose A Castro-Rodriguez; Olaia Sardón; Eduardo G Pérez-Yarza; Javier Korta; Ane Aldasoro; Paula Corcuera; Javier Mintegui
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  -     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Respiratory Medicine, Department of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile , Santiago , Chile.
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