Document Detail

You can't go home again: transcriptionally driven alteration of cell signaling by NGF.
MedLine Citation:
PMID:  16341597     Owner:  NLM     Status:  MEDLINE    
Here we review findings indicating that neurotrophins such as NGF promote changes in gene transcription that in turn influence the ways that cells subsequently respond to trophic factors. As a result, initial responses of "na?ve" cells to NGF and other trophic agents differ from those of cells with prior NGF exposure. We discuss specific examples based on reports in the literature as well as on data derived from a serial analysis of gene expression (SAGE) study of NGF-promoted transcriptional changes in PC12 pheochromocytoma cells.
Lloyd A Greene; James M Angelastro
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurochemical research     Volume:  30     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-02-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1347-52     Citation Subset:  IM    
Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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MeSH Terms
14-3-3 Proteins / metabolism
Antigens, Differentiation / metabolism
Calmodulin / metabolism
Carrier Proteins / metabolism
Cytokines / metabolism
GRB2 Adaptor Protein / metabolism
Gene Expression Regulation*
Heterotrimeric GTP-Binding Proteins / metabolism
Nerve Growth Factor / metabolism*
PC12 Cells
Pituitary Adenylate Cyclase-Activating Polypeptide / metabolism
Receptor, Epidermal Growth Factor / metabolism
Receptors, Immunologic / metabolism
Signal Transduction / physiology*
Transcription, Genetic*
Reg. No./Substance:
0/14-3-3 Proteins; 0/Antigens, Differentiation; 0/Calmodulin; 0/Carrier Proteins; 0/Cytokines; 0/GRB2 Adaptor Protein; 0/Pituitary Adenylate Cyclase-Activating Polypeptide; 0/Receptors, Immunologic; 0/SIRPA protein, human; 134034-50-7/pleiotrophin; 9061-61-4/Nerve Growth Factor; EC, Epidermal Growth Factor; EC GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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