Document Detail


Yoked delivery of cocaine is aversive and protects against the motivation for drug in rats.
MedLine Citation:
PMID:  19634952     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Experiment 1, water-deprived rats had 5-min access to saccharin followed by active or yoked intravenous delivery of saline or cocaine (0.33 mg/infusion). Both cocaine groups avoided intake of the saccharin cue following saccharin-cocaine pairings; however, the rats in the yoked condition exhibited greater avoidance of the taste cue than did the actively administering rats. Experiment 2 evaluated subsequent self-administration behavior on fixed- and progressive-ratio schedules of reinforcement. The results showed that prior yoked exposure to cocaine reduced subsequent drug-taking behavior on a progressive-ratio but not on a fixed-ratio schedule. Finally, Experiment 3 used a choice test to determine the impact of yoked drug delivery on the relative preference for cocaine versus water. The results showed that rats with a history of self-administering cocaine preferred to perform operant behaviors on the side of the chamber previously paired with cocaine, whereas the rats with a history of yoked delivery of cocaine avoided this side. These data show that, in most rats, the unpredictable, uncontrollable delivery of cocaine protects against the subsequent motivation for cocaine through an aversive mechanism.
Authors:
Robert C Twining; Matthew Bolan; Patricia S Grigson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  123     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-11-06     Revised Date:  2013-12-25    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  913-25     Citation Subset:  IM    
Copyright Information:
2009 APA, all rights reserved
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MeSH Terms
Descriptor/Qualifier:
Animals
Catheterization
Cocaine / administration & dosage*
Conditioning, Classical
Conditioning, Operant
Cues
Dopamine Uptake Inhibitors / administration & dosage*
Drinking Behavior
Male
Motivation*
Neuropsychological Tests
Physical Stimulation
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Saccharin
Self Administration
Taste Perception / drug effects
Water / administration & dosage
Grant Support
ID/Acronym/Agency:
F31 DA016512/DA/NIDA NIH HHS; R01 DA009815/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; 059QF0KO0R/Water; FST467XS7D/Saccharin; I5Y540LHVR/Cocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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