| Yogurt protects against growth retardation in weanling rats fed diets high in phytic acid. | |
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MedLine Citation:
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PMID: 19269152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the effects of adding yogurt to animal diets that were high in phytic acid (PA) and adequate in zinc (38 microg Zn/g). The PA:Zn molar ratio was 60:1. Zinc status was determined by documenting growth and measuring the zinc concentration in bone (tibia) and plasma. For 25 days, six groups (n=6) of Sprague-Dawley weanling rats were fed one of six AIN-76 diets. Half of the diets contained PA. Four of the diets contained yogurt with either active or heat-treated (inactive) cultures added at 25% of the diet. The diets were as follows: (a) AIN, (b) AIN with active yogurt, (c) AIN and inactive yogurt, (d) AIN with PA, (e) AIN with PA plus active yogurt and (f) AIN with PA plus inactive yogurt. Body weight, weight gain and zinc concentration in bone and plasma were measured, and food efficiency ratio was calculated. Rats fed diets with PA and yogurt had normal growth compared to the control group. Growth retardation was evident in the group fed the diet with PA and no yogurt. This group had significantly lower body weight compared to all other groups (P<.05). Rats fed diets with PA, with or without yogurt, had significantly lower zinc concentration in bone and plasma (P<.05). Adding yogurt to diets high in PA resulted in normal growth in weanling rats; however, zinc concentration in bone and plasma was still suboptimal. |
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Authors:
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Lisa M Gaetke; Craig J McClain; C Jean Toleman; Mary A Stuart |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-03-09 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 21 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-29 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 147-52 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Nutrition and Food Science, University of Kentucky, Lexington, KY 40506, USA. lgaetke@email.uky.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density / drug effects Chelating Agents / administration & dosage, toxicity* Diet* Hot Temperature Nutritional Status / drug effects Phytic Acid / administration & dosage, toxicity* Random Allocation Rats Rats, Sprague-Dawley Time Factors Weaning Weight Gain / drug effects* Yogurt* / microbiology Zinc / administration & dosage, analysis, blood, deficiency* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AA010496-03/AA/NIAAA NIH HHS; R01 AA010762-04/AA/NIAAA NIH HHS; R01 AA10496/AA/NIAAA NIH HHS; R01 AA10762/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 7440-66-6/Zinc; 83-86-3/Phytic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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