| Yogurt containing probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/AIDS patients. | |
| | |
MedLine Citation:
|
PMID: 18223503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
HIV/AIDS is changing the human landscape in sub-Saharan Africa. Relatively few patients receive antiretroviral therapy, and many suffer from debilitating diarrhea that affects their quality of life. Given the track record of probiotics to alleviate diarrhea, conventional yogurt fermented with Lactobacillus delbruekii var bulgaricus and Streptococcus thermophilus was supplemented with probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14. Twenty-four HIV/AIDS adult female patients (18 to 44 y) with clinical signs of moderate diarrhea, CD4 counts over 200, and not receiving antiretrovirals or dietary supplements, consumed either 100 mL supplemented or unsupplemented yogurt per day for 15 days. Hematologic profiles, CD4 cell counts, and quality of life was evaluated at baseline, 15 and 30 days postprobiotic-yogurt feeding. There was no significant alteration in the hematologic parameters of both groups before and after the probiotic-yogurt feeding. The probiotic yogurt group at baseline, 15 and 30 days had a mean WBC count of 5.8+/-0.76 x 10(9)/L, 6.0+/-1.02 x 10(9)/L, and 5.4+/-0.14 x 10(9)/L, respectively. However, the mean CD4 cell count remained the same or increased at 15 and 30 days in 11/12 probiotic-treated subjects compared to 3/12 in the control. Diarrhea, flatulence, and nausea resolved in 12/12 probiotic-treated subjects within 2 days, compared to 2/12 receiving yogurt for 15 days. This is the first study to show the benefits of probiotic yogurt on quality of life of women in Nigeria with HIV/AIDS, and suggests that perhaps a simple fermented food can provide some relief in the management of the AIDS epidemic in Africa. |
| | |
Authors:
|
Kingsley C Anukam; Emanual O Osazuwa; Humphrey B Osadolor; Andrew W Bruce; Gregor Reid |
Related Documents
:
|
17131953 - The community benefits of farm safety day camps. 11111463 - The stigma of being named "aids carriers" on haitian-american women. 10179553 - Computer-aided prescription--a prototype system. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of clinical gastroenterology Volume: 42 ISSN: 0192-0790 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2008 Mar |
Date Detail:
|
Created Date: 2008-02-21 Completed Date: 2008-05-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 239-43 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult CD4 Lymphocyte Count CD4-Positive T-Lymphocytes / immunology* Diarrhea / diet therapy*, etiology, immunology Female Follow-Up Studies HIV / immunology HIV Antibodies / immunology HIV Infections / complications*, immunology Humans Lactobacillus reuteri* Lactobacillus rhamnosus* Probiotics / therapeutic use* Quality of Life Time Factors Treatment Outcome Yogurt / microbiology* |
| Chemical | |
Reg. No./Substance:
|
0/HIV Antibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patient subjective assessment of drug side effects in inflammatory bowel disease.
Next Document: Fructose intolerance in IBS and utility of fructose-restricted diet.