| Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails. | |
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MedLine Citation:
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PMID: 22461646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 1988, eminent cell biologist Lew Tilney and newly appointed Assistant Professor of Microbiology Dan Portnoy met at a picnic and initiated a collaboration that led to a groundbreaking paper published in Journal of Cell Biology entitled "Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes." The paper has been cited more than 800 times, the most of any publication in the careers of both investigators. Using an electron microscope from the Sputnik era, they assembled a stunning collection of micrographs that illustrated how L. monocytogenes enters the host cell and exploits a host system of actin-based motility to move within cells and into neighboring cells without leaving the host cell cytosol. This research captured the imagination of cell biologists and microbiologists alike and led to novel insights into cytoskeletal dynamics. Here, Portnoy provides a retrospective that shares text from the original submission that was deleted at the time of publication, along with reviewers' comments ranging from "It is really just a show and tell paper and doesn';t have any meat" to "the finding will have major impact in cell biology and in medicine. Potentially, the paper will be a classic." |
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Authors:
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Daniel A Portnoy |
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Publication Detail:
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Type: Autobiography; Biography; Historical Article; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Molecular biology of the cell Volume: 23 ISSN: 1939-4586 ISO Abbreviation: Mol. Biol. Cell Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-30 Completed Date: 2012-09-13 Revised Date: 2013-03-05 |
Medline Journal Info:
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Nlm Unique ID: 9201390 Medline TA: Mol Biol Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1141-5 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cell Biology and School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA. portnoy@berkeley.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actin Cytoskeleton
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microbiology,
physiology Bacteriology / history* History, 20th Century Host-Pathogen Interactions Humans Listeria monocytogenes / pathogenicity, physiology*, ultrastructure Philadelphia |
| Grant Support | |
ID/Acronym/Agency:
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P01 AI063302/AI/NIAID NIH HHS; R01 AI27655/AI/NIAID NIH HHS |
| Personal Name Subject | |
Personal Name Subject:
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Daniel A Portnoy |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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