| The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. | |
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MedLine Citation:
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PMID: 8673557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent data support the hypothesis that the fatty streak develops in response to specific phospholipids contained in LDL that become trapped in the artery wall and become oxidized as a result of exposure to the oxidative waste of the artery wall cells. The antioxidants present within both LDL and the microenvironments in which LDL is trapped function to prevent the formation of these biologically active, oxidized lipids. Enzymes associated with LDL and HDL (eg, platelet activating factor acetylhydrolase) or with HDL alone (eg, paraoxonase) destroy these biologically active lipids. The regulation and expression of these enzymes are determined genetically and are also significantly modified by environmental influences, including the acute-phase response or an atherogenic diet. The balance of these multiple factors leads to an induction or suppression of the inflammatory response in the artery wall and determines the clinical course. |
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Authors:
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M Navab; J A Berliner; A D Watson; S Y Hama; M C Territo; A J Lusis; D M Shih; B J Van Lenten; J S Frank; L L Demer; P A Edwards; A M Fogelman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 16 ISSN: 1079-5642 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-08-15 Completed Date: 1996-08-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 831-42 Citation Subset: IM |
Affiliation:
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Atherosclerosis Research Unit, School of Medicine, University of California at Los Angeles 90095-1736, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / metabolism Arteriosclerosis / etiology*, genetics Humans Lipid Peroxidation* Lipoproteins, HDL / metabolism Lipoproteins, LDL / metabolism Phospholipids / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL 30568/HL/NHLBI NIH HHS; RR-865/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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