Document Detail


The Yin and Yang of Signaling in Tregs and TH17 Cells.
MedLine Citation:
PMID:  21427407     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Substantial advances in our understanding of the developmental and functional relationship between regulatory T cells (T(regs)) and T helper 17 (T(H)17) cells and their potential clinical applications have been made. In response to these breakthroughs, the second international conference entitled "China Tregs/Th17 2010 Shanghai Conference," held in Shanghai, China, was dedicated to this topic. Various types of T(regs) and T(H)17 cells, as well as their relevant cytokines, were discussed. Here, we summarize some of the findings shared at the conference, specifically focusing on the biology of T(H)17 cells, including interleukin-17 (IL-17)-producing innate cells, T(regs), and the factors that control the critical balance between T(regs) and cells of the T(H)17 lineage.
Authors:
Fan Pan; Huimin Fan; Ling Lu; Zhongmin Liu; Shuiping Jiang
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Publication Detail:
Type:  Journal Article     Date:  2011-03-22
Journal Detail:
Title:  Science signaling     Volume:  4     ISSN:  1937-9145     ISO Abbreviation:  Sci Signal     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465400     Medline TA:  Sci Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  mr4     Citation Subset:  IM    
Affiliation:
1Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
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