Document Detail

Yield of sputum induction in the diagnosis of pleural tuberculosis.
MedLine Citation:
PMID:  12598215     Owner:  NLM     Status:  MEDLINE    
We prospectively evaluated the diagnostic yield of acid-fast bacilli smear and culture for Mycobacterium tuberculosis using sputum induction (SI) in the workup of patients with suspected pleural tuberculosis (TB) who were unable to produce sputum spontaneously. Of the 113 patients studied, a final diagnosis of pleural TB was made in 84 patients (71 HIV seronegative) and a final diagnosis of another disease in 29 patients. Histopathologic examination of the pleural biopsy tissue had the highest diagnostic yield (78%; 66/84). The bacteriologic yield was 62% (52/84) for the pleural tissue, 12% (10/84) for pleural fluid, and 52% (44/84) for sputum cultures obtained by SI. The yield of SI culture for M. tuberculosis was 55% (35/64) in patients with a normal radiograph (except for the pleural effusion) and 45% (9/20) in those with evidence of parenchymal disease suggestive of pulmonary TB (p = 0.6). The yield of sputum cultures obtained by SI is high in patients suspected of having pleural TB even in those cases with no pulmonary parenchymal abnormalities on the chest radiograph.
Marcus B Conde; Angela Chindamo Loivos; Valeria M Rezende; Sergio L M Soares; Fernanda C Q Mello; Arthur L Reingold; Charles L Daley; Afranio L Kritski
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  167     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-5     Citation Subset:  AIM; IM    
Divisão de Tisiologia e Pneumologia, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Brazil.
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MeSH Terms
Aged, 80 and over
Chi-Square Distribution
Data Interpretation, Statistical
Diagnostic Techniques, Respiratory System
HIV Seronegativity
HIV Seropositivity
Middle Aged
Mycobacterium tuberculosis / isolation & purification*
Pleura / microbiology,  pathology
Pleural Effusion / microbiology
Prospective Studies
Radiography, Thoracic
Sputum / microbiology*
Tuberculosis, Pleural / diagnosis*,  microbiology,  pathology,  radiography
Grant Support
Comment In:
Am J Respir Crit Care Med. 2003 Mar 1;167(5):676-7   [PMID:  12598210 ]

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