| Yessotoxin induces apoptosis in HL7702 human liver cells. | |
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MedLine Citation:
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PMID: 21964741 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The marine toxin yessotoxin (YTX) is found in numerous aquatic environments and poses a potential threat to the shellfish industry and to public health. We analyzed the toxicity of YTX on HL7702 human liver cells using optical microscopy, Hoechst 33342 chromatin staining, DNA gel electrophoresis, rhodamine 123 staining and calcium-sensitive laser scanning confocal microscopy. The results demonstrated that YTX induced the usual hallmarks of apoptosis, including chromatin condensation, DNA laddering, activity of caspase-3 deregulation and loss of mitochondrial membrane potential. Furthermore, YTX caused cytosolic calcium levels to increase in HL7702 cells. YTX may cause liver damage through hepatocyte apoptosis. |
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Authors:
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Min Pang; Pei Qu; Chun-Lei Gao; Zong-Ling Wang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-30 |
Journal Detail:
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Title: Molecular medicine reports Volume: - ISSN: 1791-3004 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The First Institute of Oceanography, State Oceanic Administration, Qingdao 266061, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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