Document Detail

Yersiniae and iron. A study in host-parasite relationships.
MedLine Citation:
PMID:  3311635     Owner:  NLM     Status:  MEDLINE    
Most enterobacteria obtain the iron they require for growth by producing low-molecular-weight high-affinity iron ligands known as siderophores. These substances chelate and solubilize iron making it available to bacteria. The pathogenic Yersiniae produce no detectable siderophores; thus, they proliferate poorly or not at all under conditions of iron limitation. Most systemic infections with Yersinia enterocolitica occur in patients who are overloaded with iron. This may be due to the presence of excess iron in the tissues of such patients, but the adverse effects of excess iron on immune responsiveness may also be partly responsible. Many patients with iron overload receive treatment with desferrioxamine B, a bacterial siderophore which promotes growth of Y. enterocolitica in vitro and in vivo. Thus, desferrioxamine B may add to the risk of systemic yersiniosis developing in patients with siderosis. Some strains of Yersinia frederiksenii, Yersinia intermedia and Yersinia kristensenii produce the hydroxamate siderophore aerobactin, but, paradoxically, they appear to be unable to proliferate in tissues.
R M Robins-Browne; J K Prpic; S J Stuart
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contributions to microbiology and immunology     Volume:  9     ISSN:  0301-3081     ISO Abbreviation:  Contrib. Microbiol. Immunol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-12-03     Completed Date:  1987-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401476     Medline TA:  Contrib Microbiol Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Department of Microbiology, University of Melbourne, Parkville, Vict., Australia.
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MeSH Terms
Deferoxamine / pharmacology
Iron / metabolism*
Siderosis / complications,  drug therapy
Yersinia / metabolism*,  pathogenicity
Yersinia Infections / etiology*
Reg. No./Substance:
70-51-9/Deferoxamine; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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