| Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling. | |
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MedLine Citation:
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PMID: 22565313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal barrier function requires intricate cooperation between intestinal epithelial cells and immune cells. Enteropathogens are able to invade the intestinal lymphoid tissue known as Peyer's patches (PPs) and disrupt the integrity of the intestinal barrier. However, the underlying molecular mechanisms of this process are poorly understood. In mice infected with Yersinia pseudotuberculosis, we found that PP barrier dysfunction is dependent on the Yersinia virulence plasmid and the expression of TLR-2 by hematopoietic cells, but not by intestinal epithelial cells. Upon TLR-2 stimulation, Y. pseudotuberculosis-infected monocytes activated caspase-1 and produced IL-1β. In turn, IL-1β increased NF-κB and myosin light chain kinase activation in intestinal epithelial cells, thus disrupting the intestinal barrier by opening the tight junctions. Therefore, Y. pseudotuberculosis subverts intestinal barrier function by altering the interplay between immune and epithelial cells during infection. |
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Authors:
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Camille Jung; Ulrich Meinzer; Nicolas Montcuquet; Elodie Thachil; Danielle Château; Raphaële Thiébaut; Maryline Roy; Ziad Alnabhani; Dominique Berrebi; Monique Dussaillant; Eric Pedruzzi; Sophie Thenet; Nadine Cerf-Bensussan; Jean-Pierre Hugot; Frederick Barreau |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-05-08 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 122 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-06-01 Completed Date: 2012-08-20 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 2239-51 Citation Subset: AIM; IM |
Affiliation:
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Université Paris-Diderot, UMR843, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caco-2 Cells Caspase 1 / genetics, immunology Enzyme Activation / genetics, immunology Hematopoietic Stem Cells / immunology*, microbiology, pathology Humans Interleukin-1beta / genetics, immunology Intestinal Mucosa / immunology*, microbiology, pathology Mice Mice, Knockout Monocytes / immunology, microbiology, pathology Myosin-Light-Chain Kinase / genetics, immunology NF-kappa B / genetics, immunology Peyer's Patches / immunology*, microbiology, pathology Signal Transduction / genetics, immunology* Toll-Like Receptor 2 / genetics, immunology* Yersinia pseudotuberculosis / genetics, immunology* Yersinia pseudotuberculosis Infections / genetics, immunology*, pathology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/NF-kappa B; 0/Tlr2 protein, mouse; 0/Toll-Like Receptor 2; EC 2.7.11.18/Myosin-Light-Chain Kinase; EC 3.4.22.36/Caspase 1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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