Document Detail


Yersinia--flea interactions and the evolution of the arthropod-borne transmission route of plague.
MedLine Citation:
PMID:  22406208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Yersinia pestis, the causative agent of plague, is unique among the enteric group of Gram-negative bacteria in relying on a blood-feeding insect for transmission. The Yersinia-flea interactions that enable plague transmission cycles have had profound historical consequences as manifested by human plague pandemics. The arthropod-borne transmission route was a radical ecologic change from the food-borne and water-borne transmission route of Yersinia pseudotuberculosis, from which Y. pestis diverged only within the last 20000 years. Thus, the interactions of Y. pestis with its flea vector that lead to colonization and successful transmission are the result of a recent evolutionary adaptation that required relatively few genetic changes. These changes from the Y. pseudotuberculosis progenitor included loss of insecticidal activity, increased resistance to antibacterial factors in the flea midgut, and extending Yersinia biofilm-forming ability to the flea host environment.
Authors:
Iman Chouikha; B Joseph Hinnebusch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2012-03-07
Journal Detail:
Title:  Current opinion in microbiology     Volume:  15     ISSN:  1879-0364     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-24     Completed Date:  2013-02-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-46     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Affiliation:
Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Evolution
Host-Pathogen Interactions
Insect Vectors / microbiology*
Plague / microbiology,  transmission*
Siphonaptera / microbiology*
Yersinia pestis / pathogenicity*
Grant Support
ID/Acronym/Agency:
Z01 AI000796-11/AI/NIAID NIH HHS; Z01 AI000796-12/AI/NIAID NIH HHS
Comments/Corrections

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