| Yersinia--flea interactions and the evolution of the arthropod-borne transmission route of plague. | |
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MedLine Citation:
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PMID: 22406208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Yersinia pestis, the causative agent of plague, is unique among the enteric group of Gram-negative bacteria in relying on a blood-feeding insect for transmission. The Yersinia-flea interactions that enable plague transmission cycles have had profound historical consequences as manifested by human plague pandemics. The arthropod-borne transmission route was a radical ecologic change from the food-borne and water-borne transmission route of Yersinia pseudotuberculosis, from which Y. pestis diverged only within the last 20000 years. Thus, the interactions of Y. pestis with its flea vector that lead to colonization and successful transmission are the result of a recent evolutionary adaptation that required relatively few genetic changes. These changes from the Y. pseudotuberculosis progenitor included loss of insecticidal activity, increased resistance to antibacterial factors in the flea midgut, and extending Yersinia biofilm-forming ability to the flea host environment. |
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Authors:
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Iman Chouikha; B Joseph Hinnebusch |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2012-03-07 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 15 ISSN: 1879-0364 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-07-24 Completed Date: 2013-02-07 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 239-46 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Evolution Host-Pathogen Interactions Insect Vectors / microbiology* Plague / microbiology, transmission* Siphonaptera / microbiology* Yersinia pestis / pathogenicity* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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