Document Detail


Yeast replicative DNA polymerases and their role at the replication fork.
MedLine Citation:
PMID:  11804324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The budding yeast, Saccharomyces cerevisiae, is an excellent model system for the study of DNA polymerases and their roles in DNA replication, repair, and recombination. Presently ten DNA polymerases have been purified and characterized from S. cerevisiae. Rapid advances in genome sequencing projects for yeast and other organisms have greatly facilitated and accelerated the identification of yeast enzymes and their homologues in other eukaryotic species. This article reviews current available research on yeast DNA polymerases and their functional roles in DNA metabolism. Relevant information about eukaryotic homologues of these enzymes will also be discussed.
Authors:
Y Kawasaki; A Sugino
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Molecules and cells     Volume:  12     ISSN:  1016-8478     ISO Abbreviation:  Mol. Cells     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-08-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9610936     Medline TA:  Mol Cells     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  277-85     Citation Subset:  IM    
Affiliation:
Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
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MeSH Terms
Descriptor/Qualifier:
DNA-Directed DNA Polymerase / genetics,  metabolism*
Multigene Family
Protein Structure, Tertiary / genetics
Saccharomyces cerevisiae / enzymology*
Chemical
Reg. No./Substance:
EC 2.7.7.7/DNA-Directed DNA Polymerase

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